Evidence map›Paper›PMID 39896795›Full record

ArticleIDCases2025

Necrotic erythema nodosum leprosum - A case of severe lepromatous reaction in a multibacillary leprosy patient.

Hrithik Dakssesh Putta Nagarajan, Balakrishnan Kamaraj, Keerthivasan Selvanathan, Shubham Kumar, Shilpa Gaidhane, Sanjit Sah, Prakasini Satapathy, Rachana Mehta, Rodrigue Ndabashinze, Amogh Verma

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In one paragraph

Article in IDCases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hrithik Dakssesh Putta NagarajanMadurai Medical College, Madurai, Tamil Nadu, India.
Balakrishnan KamarajMadurai Medical College, Madurai, Tamil Nadu, India.
Keerthivasan SelvanathanMadurai Medical College, Madurai, Tamil Nadu, India.
Shubham KumarCenter for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.
Shilpa GaidhaneOne Health Centre (COHERD), Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education, Wardha, India.
Sanjit SahDepartment of Paediatrics, Dr. D. Y. Patil Medical College Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth (Deemed-to-be-University), Pimpri, Pune, Maharashtra 411018, India.
Prakasini SatapathyUniversity Center for Research and Development, Chandigarh University, Mohali, Punjab, India.
Rachana MehtaClinical Microbiology, RDC, Manav Rachna International Institute of Research and Studies, Faridabad, Haryana 121004, India.
Rodrigue NdabashinzeUniversity of Burundi, Bujumbura, Burundi.
Amogh VermaDepartment of Internal Medicine, Rama Medical College Hospital and Research Center, Hapur, Uttar Pradesh, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Necrotic erythema nodosum leprosum (ENL) is an uncommon and severe complication of multibacillary leprosy, characterized by intense systemic inflammation, ulcerative lesions, and significant morbidity. This case report describes a 32-year-old male presenting with recurrent type 2 lepra reactions and necrotic lesions exacerbated by inconsistent adherence to multidrug therapy (MDT). The patient's management involved MDT, corticosteroids, thalidomide, and hydroxychloroquine, which led to a substantial clinical improvement. Emerging evidence and a multidisciplinary approach have been used to address this complex pathophysiology and clinical presentation. This report demonstrates the necessity for uninterrupted treatment, early recognition, and tailored therapeutic interventions for managing severe lepra reactions.

Indexed as

Erythema nodosum leprosumImmunomodulationLeprosyMultidrug therapyNecrotic lesionsThalidomide

Identifiers

PMID39896795
PMCPMC11786067

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.