Evidence map›Paper›PMID 39896732›Full record

ArticleCurrent developments in nutrition2025

Effect of Daily Fiber Intake Among Cirrhotic Patients With and Without Portosystemic Shunts.

Simona Parisse, Sara Carnevale, Elio Damato, Flaminia Ferri, Monica Mischitelli, Mario Corona, Pierleone Lucatelli, Alfredo Cantafora, Adriano De Santis, Domenico Alvaro and 2 more

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Article in Current developments in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The Conundrum of XenomiRs and Human Health.Advances in nutrition (Bethesda, Md.) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Simona ParisseDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Sara CarnevaleBelcolle Hospital, Viterbo, Italy.
Elio DamatoDepartment of Radiological, Oncological and Anatomopathological Sciences, Sapienza University of Rome, Rome, Italy.
Flaminia FerriDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Monica MischitelliDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Mario CoronaDepartment of Radiological, Oncological and Anatomopathological Sciences, Sapienza University of Rome, Rome, Italy.
Pierleone LucatelliDepartment of Radiological, Oncological and Anatomopathological Sciences, Sapienza University of Rome, Rome, Italy.
Alfredo CantaforaDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Adriano De SantisDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Domenico AlvaroDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Maurizio MuscaritoliDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Stefano Ginanni CorradiniDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: A diet rich in fiber, especially soluble fiber, causes cholestatic liver damage and fibrosis in animal models with intestinal dysbiosis, high serum bile acid concentrations, and congenital portosystemic shunts (PSs), but no data on patients with cirrhosis (CIRs) are available. Objectives: To investigate whether dietary fiber consumption was associated with clinical outcomes of CIRs and whether their effect differed according to the presence of PSs. Methods: Daily soluble and insoluble fiber intake was extrapolated from 3-d food diaries in 25 patients with chronic hepatitis (CH) and 80 CIRs outpatient liver transplant candidates abstinent from alcohol and nonviremic for ≥6 mo. In CIRs, the presence of PSs was verified by computed tomography, and the model for end-stage liver disease (MELD) score was calculated at enrollment and after 6 mo. Results: PSs were present in 48 (60%) CIRs. The MELD score after 6 mo, compared with enrollment, had improved in 19 and 10 CIRs with and without PSs, respectively. By adjusting for confounders in logistic regression models we found that improvement in MELD over time was inversely associated with insoluble fiber consumption expressed in milligrams per kilogram (mg/kg) body weight in CIRs without PSs [odds ratio (OR): 0.968; 95% confidence interval (CI): 0.939, 0.997; Conclusions: The clinical impact of dietary fiber changes from beneficial to harmful as the stage of chronic liver disease progresses. In particular, in the advanced cirrhosis stage with PSs, soluble fiber intake appears to significantly influence disease progression and should be kept low.

Indexed as

cirrhosiscirrhotic dietliver damageliver transplantationMELD

Identifiers

PMID39896732
PMCPMC11787017

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.