Evidence map›Paper›PMID 39896661›Full record

ArticlebioRxiv : the preprint server for biology2025

Convergent Agonist and Heat Activation of Nociceptor TRPM3.

Sushant Kumar, Fei Jin, Sung Jin Park, Wooyoung Choi, Sarah I Keuning, Richard P Massimino, Simon Vu, Wei Lü, Juan Du

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Sushant KumarDepartment of Molecular Biosciences, Northwestern University, Evanston, IL, USA.
Fei JinDepartment of Molecular Biosciences, Northwestern University, Evanston, IL, USA.
Sung Jin ParkDepartment of Molecular Biosciences, Northwestern University, Evanston, IL, USA.
Wooyoung ChoiDepartment of Molecular Biosciences, Northwestern University, Evanston, IL, USA.
Sarah I KeuningDepartment of Molecular Biosciences, Northwestern University, Evanston, IL, USA.
Richard P MassiminoDepartment of Molecular Biosciences, Northwestern University, Evanston, IL, USA.
Simon VuDepartment of Molecular Biosciences, Northwestern University, Evanston, IL, USA.
Wei LüDepartment of Molecular Biosciences, Northwestern University, Evanston, IL, USA.
Juan DuDepartment of Molecular Biosciences, Northwestern University, Evanston, IL, USA.

Funding

Structural and Functional Studies of the TRPM4 and TRPM5 ChannelsR01HL153219 · NHLBI · VAN ANDEL RESEARCH INSTITUTE · PI Wei Lu · 2020 to 2026
$3.9M
Structural Basis of Nociceptor Channel TRPM3 gating and pharmacologyR01NS129804 · NINDS · VAN ANDEL RESEARCH INSTITUTE · PI Juan Du · 2023 to 2026
$2.8M
Structural and functional studies of the TRPM2 channelR01NS111031 · NINDS · VAN ANDEL RESEARCH INSTITUTE · PI DU, JUAN · 2019 to 2023
$2.7M
Structural and functional studies of CALHM channelsR01NS112363 · NINDS · VAN ANDEL RESEARCH INSTITUTE · PI LU, WEI · 2020 to 2024
$2.3M
NHLBI NIH HHS R01 HL153219NINDS NIH HHS R01 NS111031NINDS NIH HHS R01 NS112363NINDS NIH HHS R01 NS129804
6 · The paper itself

Abstract

Detecting noxious heat is vital for survival, triggering pain responses that protect against harm

Identifiers

PMID39896661
PMCPMC11785169

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.