Evidence map›Paper›PMID 39896654›Full record

ArticlebioRxiv : the preprint server for biology2025

Ciliopathy-associated protein, CEP290, is required for ciliary necklace and outer segment membrane formation in retinal photoreceptors.

Abigail R Moye, Michael A Robichaux, Melina A Agosto, Carlo Rivolta, Alexandre P Moulin, Theodore G Wensel

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Abigail R MoyeInstitute of Molecular and Clinical Ophthalmology Basel (IOB), Basel, 4031, Switzerland.
Michael A RobichauxDepartment of Ophthalmology & Visual Sciences and Department of Biochemistry & Molecular Medicine, West Virginia University, Morgantown, West Virginia, USA.
Melina A AgostoRetina and Optic Nerve Research Laboratory, Department of Physiology and Biophysics, and Department of Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada.
Carlo RivoltaInstitute of Molecular and Clinical Ophthalmology Basel (IOB), Basel, 4031, Switzerland.ORCID 0000-0002-0733-9950
Alexandre P MoulinJules-Gonin Eye Hospital, Fondation Asile des Aveugles, University of Lausanne, 1004 Lausanne, Switzerland.
Theodore G WenselVerna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, USA.

Funding

Cilium-Associated Structures in Rod CellsR01EY026545 · NEI · BAYLOR COLLEGE OF MEDICINE · PI WENSEL, THEODORE G · 2016 to 2024
$3.7M
REGULATION AND FUNCTION OF RETINAL PHOSPHOINOSITIDESR01EY031949 · NEI · BAYLOR COLLEGE OF MEDICINE · PI WENSEL, THEODORE G · 2020 to 2023
$1.6M
Cep290 function in photoreceptor structure and disease.F32EY031574 · NEI · BAYLOR COLLEGE OF MEDICINE · PI MOYE, ABIGAIL R · 2021 to 2022
$128k
NEI NIH HHS F32 EY031574NEI NIH HHS R01 EY026545NEI NIH HHS R01 EY031949
6 · The paper itself

Abstract

The most common genetic cause of the childhood blinding disease Leber Congenital Amaurosis is mutation of the ciliopathy gene

Indexed as

CEP290ciliary necklaceconnecting ciliumphotoreceptorstransition zoneY-links

Identifiers

PMID39896654
PMCPMC11785020

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.