Evidence map›Paper›PMID 39896649›Full record

ArticlebioRxiv : the preprint server for biology2025

DNAHX: a novel, non-motile dynein heavy chain subfamily, identified by cryo-EM endogenously.

Pengxin Chai, Diego Suchenski Loustaunau, Wan Zheng, Jun Yang, Kai Zhang

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Pengxin ChaiDepartment of Molecular Biophysics and Biochemistry, Yale University.ORCID 0000-0001-9702-978X
Diego Suchenski LoustaunauDepartment of Molecular Biophysics and Biochemistry, Yale University.
Wan ZhengDepartment of Molecular Biophysics and Biochemistry, Yale University.
Jun YangDepartment of Molecular Biophysics and Biochemistry, Yale University.
Kai ZhangDepartment of Molecular Biophysics and Biochemistry, Yale University.ORCID 0000-0001-8617-2855

Funding

WORK ORDER 126643 B539 EXPAND IC SUITE75N91019D00024 · NIAID · LEIDOS BIOMEDICAL RESEARCH, INC. · PI BRISCOE, LYNN · 2019 to 2025
$3932.6M
Structural basis of dynein-driven ciliary motilityR35GM142959 · NIGMS · YALE UNIVERSITY · PI ZHANG, KAI JACK · 2021 to 2025
$2.3M
High-throughput electron cryo-microscopeS10OD023603 · OD · YALE UNIVERSITY · PI SIGWORTH, FREDERICK J · 2018 to 2018
$1.9M
NCI NIH HHS 75N91019D00024NIGMS NIH HHS R35 GM142959NIH HHS S10 OD023603
6 · The paper itself

Abstract

Ciliogenesis and cilia motility rely on the coordinated actions of diverse dyneins, yet the complexity of these motor proteins in cilia has posed challenges for understanding their specific roles. Traditional evolutionary analyses often overlook key family members due to technical limitations. Here, we present a cryo-EM-based, bottom-up approach for large-scale,

Identifiers

PMID39896649
PMCPMC11785096

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.