ArticlebioRxiv : the preprint server for biology2025
Breaking the Phalanx: Overcoming Bacterial Drug Resistance with Quorum Sensing Inhibitors that Enhance Therapeutic Activity of Antibiotics.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
9 authors.
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Abstract
Antibiotic-resistant bacterial infections loom over humanity as an increasingly deadly threat. There exists a dire need for new treatments, especially those that synergize with our existing arsenal of antibiotic drugs, to help overcome the gap in antibiotic efficacy and attenuate the development of new antibiotic resistance in the most dangerous pathogens. Quorum-sensing systems in bacteria drive the formation of biofilms, increase surface motility, and enhance other virulence factors, making these systems attractive targets for the discovery of novel antibacterials. Quorum-sensing inhibitors (QSIs) are hypothesized to synergize with existing antibiotics, making bacteria more sensitive to the effects of these drugs. In this study, we aimed to find the synergistic combinations between the QSIs and known antibiotics to combat the two deadliest hospital infections -
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Registered trials
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