Evidence map›Paper›PMID 39896625›Full record

ArticlebioRxiv : the preprint server for biology2025

Aging directs the differential evolution of KRAS-driven lung adenocarcinoma.

Felicia Lazure, Stanislav Drapela, Xiaoxian Liu, John H Lockhart, Hossein Kashfi, Nadir Sarigul, Didem Ilter, Elsa R Flores, Xuefeng Wang, Inna Smalley and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Felicia LazureDepartment of Molecular Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Stanislav DrapelaDepartment of Molecular Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Xiaoxian LiuDepartment of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute, 12902 USF Magnolia Drive, Tampa, FL 33612, USA.
John H LockhartDepartment of Molecular Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Hossein KashfiDepartment of Molecular Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Nadir SarigulDepartment of Molecular Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Didem IlterDepartment of Molecular Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Elsa R FloresDepartment of Molecular Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Xuefeng WangDepartment of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute, 12902 USF Magnolia Drive, Tampa, FL 33612, USA.
Inna SmalleyDepartment of Metabolism and Physiology, Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
Alex JaegerDepartment of Molecular Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Xiaoqing YuDepartment of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute, 12902 USF Magnolia Drive, Tampa, FL 33612, USA.
Ana P GomesDepartment of Molecular Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI John L. Cleveland · 1998 to 2026
$93.5M
Epigenetic and metabolic bottlenecks of tumorigenesisR01CA279023 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI Ana da silva Gomes · 2024 to 2026
$3.1M
AGING AS A SELECTIVE PRESSURE THAT DRIVES TUMOR PROGRESSIONDP2AG077698 · NIA · H. LEE MOFFITT CANCER CTR & RES INST · PI DA SILVA GOMES, ANA · 2021 to 2024
$2.5M
Adaptations of breast cancer metastasis to the aging lungR21AG083720 · NIA · H. LEE MOFFITT CANCER CTR & RES INST · PI DA SILVA GOMES, ANA · 2023 to 2024
$463k
NCI NIH HHS P30 CA076292NCI NIH HHS R01 CA279023NIA NIH HHS DP2 AG077698NIA NIH HHS R21 AG083720
6 · The paper itself

Abstract

Lung adenocarcinoma (LUAD), the most common histological subtype of lung cancer(1, 2), is a disease of the elderly, with an average age of diagnosis of about 70 years of age(3). Older age is associated with an increased incidence of KRAS-driven LUAD(4), a particularly deadly type of LUAD characterized by treatment resistance and relapse. Despite this, our understanding of how old age shapes KRAS-driven LUAD evolution remains incomplete. While the age-related increase in cancer risk was previously ascribed to the accumulation of mutations over time, we are now beginning to consider the role of host biology as an independent factor influencing cancer. Here, we use single-cell RNA-Sequencing of KP (Kras

Identifiers

PMID39896625
PMCPMC11785146

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.