Evidence map›Paper›PMID 39896581›Full record

ArticlebioRxiv : the preprint server for biology2025

Durable reconstitution of sinonasal epithelium by transplant of CFTR gene corrected airway stem cells.

Dawn T Bravo, Sriram Vaidyanathan, Jeannette Baker, Vrishti Sinha, Esmond Tsai, Pooya Roozdar, William W Kong, Patrick J Atkinson, Zara M Patel, Peter H Hwang and 8 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Dawn T BravoDivision of Rhinology, Department of Otolaryngology, Stanford University School of Medicine, Stanford CA.ORCID 0000-0003-3629-0786
Sriram VaidyanathanCenter for Gene Therapy, Institute at Nationwide Children's Hospital, Columbus, OH.
Jeannette BakerDivision of Hematology-Oncology, Department of Medicine, Stanford University School of Medicine, Stanford CA.
Vrishti SinhaDepartment of Pediatrics, Stanford University School of Medicine, Stanford CA.
Esmond TsaiDivision of Rhinology, Department of Otolaryngology, Stanford University School of Medicine, Stanford CA.
Pooya RoozdarDivision of Rhinology, Department of Otolaryngology, Stanford University School of Medicine, Stanford CA.
William W KongInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford CA.
Patrick J AtkinsonDivision of Rhinology, Department of Otolaryngology, Stanford University School of Medicine, Stanford CA.
Zara M PatelDivision of Rhinology, Department of Otolaryngology, Stanford University School of Medicine, Stanford CA.
Peter H HwangDivision of Rhinology, Department of Otolaryngology, Stanford University School of Medicine, Stanford CA.
Vidya K RaoDivision of Cardiac Anesthesia, Department of Anesthesiology, Stanford University School of Medicine, Stanford CA.
Robert S NegrinDivision of Hematology-Oncology, Department of Medicine, Stanford University School of Medicine, Stanford CA.
Jeffrey J WineInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford CA.
Carlos MillaCenter for Excellence in Pulmonary Biology, Stanford University School of Medicine, Stanford CA.
Zachary M SellersDivision of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Stanford University School of Medicine, Stanford CA.ORCID 0000-0001-5352-7760
Tushar J DesaiInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford CA.
Matthew H PorteusDepartment of Pediatrics, Stanford University School of Medicine, Stanford CA.ORCID 0000-0002-3850-4648
Jayakar V NayakDivision of Rhinology, Department of Otolaryngology, Stanford University School of Medicine, Stanford CA.

Funding

Optimizing Surgical Transplant of CFTR Gene-Corrected Human Basal Stem Cells to the Upper AirwayR01HL151677 · NHLBI · STANFORD UNIVERSITY · PI NAYAK, JAYAKAR V · 2021 to 2025
$2.4M
A universal genome editing strategy to develop an airway stem cell therapy for cystic fibrosisK99HL151900 · NHLBI · STANFORD UNIVERSITY · PI VAIDYANATHAN, SRIRAM · 2021 to 2022
$333k
NHLBI NIH HHS K99 HL151900NHLBI NIH HHS R01 HL151677
6 · The paper itself

Abstract

Modulator agents that restore cystic fibrosis transmembrane conductance regulator (CFTR) function have revolutionized outcomes in cystic fibrosis, an incurable multisystem disease. Barriers exist to modulator use, making local CFTR gene and cell therapies attractive, especially in the respiratory tract. We used CRISPR to gene-correct CFTR in upper airway basal stem cells (UABCs) and show durable local engraftment into recipient murine respiratory epithelium. Interestingly, the human cells recapitulate the

Indexed as

Basal cellBioluminescenceCFCRISPRCystic FibrosisGene CorrectionGene EditingGFPLower AirwayLuciferaserespiratory epitheliumStem cell transplantationUpper Airway

Identifiers

PMID39896581
PMCPMC11785248

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.