Evidence map›Paper›PMID 39896577›Full record

ArticlebioRxiv : the preprint server for biology2025

Defining the cell and molecular origins of the primate ovarian reserve.

Sissy E Wamaitha, Ernesto J Rojas, Francesco Monticolo, Fei-Man Hsu, Enrique Sosa, Amanda M Mackie, Kiana Oyama, Maggie Custer, Melinda Murphy, Diana J Laird and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Sissy E WamaithaDepartment of Molecular, Cell and Developmental Biology, University of California Los Angeles; Los Angeles, CA 90095, USA.ORCID 0000-0001-6245-6255
Ernesto J RojasDepartment of Obstetrics, Gynecology and Reproductive Science, Center for Reproductive Sciences, Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research; University of California, San Francisco; San Francisco, CA 94143, United States.
Francesco MonticoloCutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School; Boston, MA 02114, USA.
Fei-Man HsuDepartment of Molecular, Cell and Developmental Biology, University of California Los Angeles; Los Angeles, CA 90095, USA.
Enrique SosaDepartment of Molecular, Cell and Developmental Biology, University of California Los Angeles; Los Angeles, CA 90095, USA.
Amanda M MackieDepartment of Molecular, Cell and Developmental Biology, University of California Los Angeles; Los Angeles, CA 90095, USA.
Kiana OyamaDivision of Reproductive & Developmental Sciences, Oregon National Primate Research Center; Beaverton, OR 97006, USA.
Maggie CusterDivision of Reproductive & Developmental Sciences, Oregon National Primate Research Center; Beaverton, OR 97006, USA.
Melinda MurphyDivision of Reproductive & Developmental Sciences, Oregon National Primate Research Center; Beaverton, OR 97006, USA.
Diana J LairdDepartment of Obstetrics, Gynecology and Reproductive Science, Center for Reproductive Sciences, Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research; University of California, San Francisco; San Francisco, CA 94143, United States.
Jian ShuCutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School; Boston, MA 02114, USA.
Jon D HenneboldDivision of Reproductive & Developmental Sciences, Oregon National Primate Research Center; Beaverton, OR 97006, USA.
Amander T ClarkDepartment of Molecular, Cell and Developmental Biology, University of California Los Angeles; Los Angeles, CA 90095, USA.

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Towards a preclinical model for overcoming infertility with induced pluripotent stem cellsR01HD098278 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CLARK, AMANDER · 2019 to 2023
$3.0M
Fmr1 Function and Repeat Expansion in the Developing GermlineR01GM122902 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LAIRD, DIANA J · 2018 to 2021
$1.8M
Assessing transgenerational effects of Phthalates on primordial germ cellsR21ES023297 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LAIRD, DIANA J · 2013 to 2015
$944k
Investigating the role of apoptosis-resistance and the tumor environment on development and maintenance of sacrococcygeal teratomasF31CA284719 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Ernesto Javier Rojas · 2023 to 2026
$181k
NCATS NIH HHS UL1 TR001881NCI NIH HHS F31 CA284719NICHD NIH HHS R01 HD098278NIEHS NIH HHS R21 ES023297NIGMS NIH HHS R01 GM122902NIH HHS P51 OD011092
6 · The paper itself

Abstract

The primate ovarian reserve is established during late fetal development and consists of quiescent primordial follicles in the ovarian cortex, each composed of granulosa cells surrounding an oocyte in dictate. As late stages of fetal development are not routinely accessible for study with human tissue, we exploited the evolutionary proximity of the rhesus macaque to investigate primate follicle formation. Similar to human prenatal ovaries, the rhesus also develops multiple types of pre-granulosa (PG) cells, with the majority of primordial follicles derived from PG2 with small variable contributions from PG1. We observed that activated medullary follicles recruit fetal theca cells to establish a two-cell system for sex-steroid hormone production prior to birth, providing a cell-based explanation for mini puberty.

Identifiers

PMID39896577
PMCPMC11785033

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.