ArticlebioRxiv : the preprint server for biology2025
CAR T-cell and oncolytic virus dynamics and determinants of combination therapy success for glioblastoma.
Martina Conte, Agata Xella, Ryan T Woodall, Kevin A Cassady, Sergio Branciamore, Christine E Brown, Russell C Rockne
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
7 authors.
Martina ConteDepartment of Mathematical, Physical and Computer Sciences, University of Parma Parco Area delle Scienze 53/A, 43124, Parma, Italy.ORCID 0000-0002-8477-3267 Agata XellaIntegrated Mathematical Oncology Department, H. Lee Moffitt Cancer Center & Research Institute Tampa, Florida, United States of America.
Ryan T WoodallDivision of Mathematical Oncology and Computational Systems Biology, Department of Computational and Quantitative Medicine, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, United States of America.
Kevin A CassadyThe Center for Childhood Cancer, Abigail Wexner Research Institute at Nationwide Children's Hospital Columbus, Ohio, United States of America.
Sergio BranciamoreDivision of Mathematical Oncology and Computational Systems Biology, Department of Computational and Quantitative Medicine, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, United States of America.
Christine E BrownDepartments of Hematology & Hematopoietic Cell Transplantation and Immuno-Oncology Beckman Research Institute, City of Hope National Medical Center Duarte, California, United States of America.ORCID 0000-0003-4915-8207 Russell C RockneDivision of Mathematical Oncology and Computational Systems Biology, Department of Computational and Quantitative Medicine, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, United States of America.ORCID 0000-0002-1557-159X Funding
Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI John Charles Williams · 1985 to 2026
$86.3MClinical Evaluation of Chlorotoxin-redirected Chimeric Antigen Receptor (CAR) T cells for Treatment of GlioblastomaR01CA254271 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI BADIE, BEHNAM, BROWN, CHRISTINE · 2020 to 2024
$3.7MThe impact of interstitial fluid flow on CAR T cell trafficking, distribution, and efficacyR01NS115971 · NINDS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI BROWN, CHRISTINE, MUNSON, JENNIFER M · 2021 to 2025
$3.3MNCI NIH HHS P30 CA033572NCI NIH HHS R01 CA254271NINDS NIH HHS R01 NS115971
6 · The paper itselfAbstract
Glioblastoma is a highly aggressive and treatment-resistant primary brain cancer. While chimeric antigen receptor (CAR) T-cell therapy has demonstrated promising results in targeting these tumors, it has not yet been curative. An innovative approach to improve CAR T-cell efficacy is to combine them with other immune modulating therapies. In this study, we investigate
Indexed as
CAR T-cellsCombination therapiesGlioblastomaIL-13Rα2Oncolytic virusVirus burst size
Identifiers
PMID39896563
PMCPMC11785192
What OpenQuestion holds
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LicenceCC BY
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