Evidence map›Paper›PMID 39896537›Full record

ArticlebioRxiv : the preprint server for biology2025

Histone deacetylase-1 is required for epigenome stability in

Felicia Ebot-Ojong, Aileen R Ferraro, Farh Kaddar, Clayton Hull-Crew, Ashley W Scadden, Andrew D Klocko, Zachary A Lewis

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Felicia Ebot-OjongDepartment of Microbiology, University of Georgia, Athens, GA, 30602 USA.ORCID 0000-0002-3408-3487
Aileen R FerraroDepartment of Microbiology, University of Georgia, Athens, GA, 30602 USA.ORCID 0000-0003-0918-4486
Farh KaddarDepartment of Chemistry & Biochemistry, University of Colorado Colorado Springs, Colorado Springs, CO, 80918, USA.ORCID 0009-0008-5084-2480
Clayton Hull-CrewDepartment of Chemistry & Biochemistry, University of Colorado Colorado Springs, Colorado Springs, CO, 80918, USA.ORCID 0000-0001-5984-2972
Ashley W ScaddenDepartment of Chemistry & Biochemistry, University of Colorado Colorado Springs, Colorado Springs, CO, 80918, USA.ORCID 0000-0001-7603-1442
Andrew D KlockoDepartment of Chemistry & Biochemistry, University of Colorado Colorado Springs, Colorado Springs, CO, 80918, USA.ORCID 0000-0002-2236-672X
Zachary A LewisDepartment of Microbiology, University of Georgia, Athens, GA, 30602 USA.ORCID 0000-0002-1735-8266

Funding

Transcriptional repression by Polycomb Repressive Complex 2R01GM132644 · NIGMS · UNIVERSITY OF GEORGIA · PI LEWIS, ZACHARY · 2019 to 2022
$1.6M
Control and function of repressive chromatin domainsR35GM152134 · NIGMS · UNIVERSITY OF GEORGIA · PI Zachary Lewis · 2024 to 2026
$1.1M
Genome topology in the filamentous fungus Neurospora crassa: organizing factors and impact on genome functionR15GM140396 · NIGMS · UNIVERSITY OF COLORADO · PI KLOCKO, ANDREW DAVID · 2020 to 2025
$607k
NIGMS NIH HHS R01 GM132644NIGMS NIH HHS R15 GM140396NIGMS NIH HHS R35 GM152134
6 · The paper itself

Abstract

Polycomb group (PcG) proteins form chromatin modifying complexes that stably repress lineage- or context-specific genes in animals, plants, and some fungi. Polycomb Repressive Complex 2 (PRC2) catalyzes trimethylation of lysine 27 on histone H3 (H3K27me3) to assemble repressive chromatin. In the model fungus

Indexed as

constitutive heterochromatinfacultative heterochromatinH3K27me3histone deacetylasehistone post-translational modificationsPolycomb Repressive Complex 2

Identifiers

PMID39896537
PMCPMC11785058

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.