ArticlebioRxiv : the preprint server for biology2025
The liver clock tunes transcriptional rhythms in skeletal muscle to regulate mitochondrial function.
Valentina Sica, Tomoki Sato, Ioannis Tsialtas, Sophia Hernandez, Siwei Chen, Pierre Baldi, Pura Muñoz Cánoves, Paolo Sassone-Corsi, Kevin B Koronowski, Jacob G Smith
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
10 authors.
Valentina SicaUniversitat Pompeu Fabra (UPF), Department of Medicine and Life Sciences (MELIS), 08003 Barcelona, Spain.ORCID 0000-0003-2770-5847 Tomoki SatoLaboratory of Nutritional Biochemistry, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka 422-8526, Japan.ORCID 0000-0003-3044-6874 Ioannis TsialtasDepartment of Biochemistry & Structural Biology, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.
Sophia HernandezDepartment of Biochemistry & Structural Biology, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.
Siwei ChenInstitute for Genomics and Bioinformatics, Department of Computer Science, UCI, Irvine, CA 92697, USA.
Pierre BaldiInstitute for Genomics and Bioinformatics, Department of Computer Science, UCI, Irvine, CA 92697, USA.
Pura Muñoz CánovesUniversitat Pompeu Fabra (UPF), Department of Medicine and Life Sciences (MELIS), 08003 Barcelona, Spain.
Paolo Sassone-CorsiCenter for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.
Kevin B KoronowskiDepartment of Biochemistry & Structural Biology, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.ORCID 0000-0002-6808-1789 Jacob G SmithDepartment of Cell Biology, Physiology and Immunology, School of Biology, University of Barcelona, Barcelona, Spain.ORCID 0000-0001-5139-1054 Funding
Bioinformatics Tools for Circadian BiologyR01GM123558 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Pierre Baldi · 2017 to 2026
$2.4MElucidating dietary fructose and alcohol interactions during liver cancer developmentR01AA029124 · NIAAA · UNIVERSITY OF CALIFORNIA-IRVINE · PI JANG, CHOLSOON · 2021 to 2025
$2.0MFundamental Mechanisms of Higher-Order Circadian RhythmsR35GM150618 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Kevin B Koronowski · 2023 to 2026
$1.8MNIAAA NIH HHS R01 AA029124NIGMS NIH HHS R01 GM123558NIGMS NIH HHS R35 GM150618
6 · The paper itselfAbstract
Circadian clocks present throughout the brain and body coordinate diverse physiological processes to support daily homeostasis and respond to changing environmental conditions. The local dependencies within the mammalian clock network are not well defined. We previously demonstrated that the skeletal muscle clock controls transcript oscillations of genes involved in fatty acid metabolism in the liver, yet whether the liver clock also regulates the muscle was unknown. Here, we use hepatocyte-specific
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PMID39896530
PMCPMC11785164
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