ArticlebioRxiv : the preprint server for biology2025
17β-Estradiol Counteracts Pathological Microtubule Remodeling To Enhance Cardiac Function.
Ryan Moon, Neal T Vogel, Jenna B Mendelson, Lynn M Hartweck, John P Carney, Minwoo Kim, Melissa K Gardner, Sasha Prisco, Kurt W Prins
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
9 authors.
Ryan MoonLillehei Heart Institute, Cardiovascular Division, University of Minnesota, Minneapolis, MN.
Neal T VogelLillehei Heart Institute, Cardiovascular Division, University of Minnesota, Minneapolis, MN.
Jenna B MendelsonLillehei Heart Institute, Cardiovascular Division, University of Minnesota, Minneapolis, MN.ORCID 0000-0002-8229-385X Lynn M HartweckLillehei Heart Institute, Cardiovascular Division, University of Minnesota, Minneapolis, MN.
John P CarneyExperimental Surgical Services, Department of Surgery, University of Minnesota, Minneapolis, MN.
Minwoo KimLillehei Heart Institute, Cardiovascular Division, University of Minnesota, Minneapolis, MN.
Melissa K GardnerDepartment of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN.
Sasha PriscoLillehei Heart Institute, Cardiovascular Division, University of Minnesota, Minneapolis, MN.
Kurt W PrinsLillehei Heart Institute, Cardiovascular Division, University of Minnesota, Minneapolis, MN.ORCID 0000-0002-0364-6742 Funding
TRAINING PROGRAM IN MUSCLE RESEARCHT32AR007612 · NIAMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI JAMES M ERVASTI, DAWN A LOWE · 2001 to 2026
$11.3MGardner Lab MIRA Proposal: Microtubules and MitosisR35GM126974 · NIGMS · UNIVERSITY OF MINNESOTA · PI Melissa Gardner · 2018 to 2026
$3.4MGP130 Antagonism in Porcine RV Pressure OverloadR01HL162927 · NHLBI · UNIVERSITY OF MINNESOTA · PI Kurt W Prins · 2022 to 2026
$3.3MMulti-scale Investigation of Sex Differences in Right Ventricular Function via Estrogen-Microtubule InteractionsR01HL158795 · NHLBI · UNIVERSITY OF MINNESOTA · PI Kurt W Prins · 2022 to 2026
$2.8MModulating the Microbiome to Enhance Right Ventricular Function in Pulmonary Arterial HypertensionK08HL168166 · NHLBI · UNIVERSITY OF MINNESOTA · PI Sasha Zheng Prisco · 2024 to 2026
$525kMechanisms of Large Animal RV DysfunctionF31HL170585 · NHLBI · UNIVERSITY OF MINNESOTA · PI MENDELSON, JENNA BLAIR · 2024 to 2025
$71kNHLBI NIH HHS F31 HL170585NHLBI NIH HHS K08 HL168166NHLBI NIH HHS R01 HL158795NHLBI NIH HHS R01 HL162927NIAMS NIH HHS T32 AR007612NIGMS NIH HHS R35 GM126974
6 · The paper itselfAbstract
The female-predominate sex hormone 17β-estradiol exerts cardioprotective effects via multiple mechanisms. Available data demonstrate 17β-estradiol modulates microtubule dynamics
Identifiers
PMID39896522
PMCPMC11785224
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