Evidence map›Paper›PMID 39896491›Full record

ArticlebioRxiv : the preprint server for biology2025

ADAR1 haploinsufficiency and sustained picornaviral RdRp dsRNA synthesis synergize to dysregulate RNA editing and cause multi-system interferonopathy.

Caitlin M Miller, James H Morrison, Laura Bankers, Rachael Dran, Julia M Kendrick, Emma Briggs, Virginia L Ferguson, Eric M Poeschla

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Caitlin M MillerDivision of Infectious Diseases, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, Colorado, USA 80045.
James H MorrisonDivision of Infectious Diseases, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, Colorado, USA 80045.
Laura BankersDivision of Infectious Diseases, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, Colorado, USA 80045.
Rachael DranDivision of Infectious Diseases, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, Colorado, USA 80045.
Julia M KendrickDivision of Infectious Diseases, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, Colorado, USA 80045.
Emma BriggsDepartment of Mechanical Engineering and BioFrontiers Institute, University of Colorado at Boulder, Boulder, CO, 80309.
Virginia L FergusonDepartment of Mechanical Engineering and BioFrontiers Institute, University of Colorado at Boulder, Boulder, CO, 80309.
Eric M PoeschlaDivision of Infectious Diseases, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, Colorado, USA 80045.ORCID 0000-0003-1598-5415

Funding

Novel Approaches to Innate Immunity Against HIV-1 and Other Co-infection VirusesDP1DA043915 · NIDA · UNIVERSITY OF COLORADO DENVER · PI POESCHLA, ERIC M. · 2017 to 2021
$3.9M
NIDA NIH HHS DP1 DA043915
6 · The paper itself

Abstract

Sensing of viral double-stranded RNA by MDA5 triggers abundant but transient interferon-stimulated gene (ISGs) expression. If dsRNA synthesis is made persistent by transgenically expressing a picornaviral RNA-dependent RNA polymerase (RdRp) in mice, lifelong MDA5-MAVS pathway activation and marked, global ISG upregulation result. This confers robust protection from viral diseases but in contrast to numerous other chronic MDA5 hyperactivation states, the mice suffer no autoimmune or other health consequences. Here we find they further confound expectations by being resistant to a strong autoimmunity (lupus) provocation. However, knockout of one allele of

Indexed as

ADAR1autoimmunityautoinflammationinnate antiviral immunityinterferonopathylupusMDA5picornavirusRdRp

Identifiers

PMID39896491
PMCPMC11785089

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.