Evidence map›Paper›PMID 39896482›Full record

ArticlebioRxiv : the preprint server for biology2025

Markovian State Models uncover Casein Kinase 1 dynamics that govern circadian period.

Clarisse Gravina Ricci, Jonathan M Philpott, Megan R Torgrimson, Alfred M Freeberg, Rajesh Narasimamurthy, Emilia Pécora de Barros, Rommie Amaro, David M Virshup, J Andrew McCammon, Carrie L Partch

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Clarisse Gravina RicciDepartment of Chemistry and Biochemistry, University of California San Diego, San Diego, California, United States.
Jonathan M PhilpottDepartment of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, California, United States.
Megan R TorgrimsonDepartment of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, California, United States.
Alfred M FreebergDepartment of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, California, United States.
Rajesh NarasimamurthyProgram in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore.
Emilia Pécora de BarrosDepartment of Chemistry and Biochemistry, University of California San Diego, San Diego, California, United States.
Rommie AmaroDepartment of Chemistry and Biochemistry, University of California San Diego, San Diego, California, United States.ORCID 0000-0002-9275-9553
David M VirshupProgram in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore.ORCID 0000-0001-6976-850X
J Andrew McCammonDepartment of Chemistry and Biochemistry, University of California San Diego, San Diego, California, United States.
Carrie L PartchDepartment of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, California, United States.ORCID 0000-0002-4677-2861

Funding

Structures and mechanisms of circadian rhythms from cyanobacteria to humansR35GM141849 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI PARTCH, CARRIE L · 2021 to 2025
$4.6M
NIGMS NIH HHS R35 GM141849
6 · The paper itself

Abstract

Circadian rhythms in mammals are tightly regulated through phosphorylation of Period (PER) proteins by Casein Kinase 1 (CK1, subtypes δ and ε). CK1 acts on at least two different regions of PER with opposing effects: phosphorylation of phosphodegron (pD) regions leads to PER degradation, while phosphorylation of the Familial Advanced Sleep Phase (FASP) region leads to PER stabilization. To investigate how substrate selectivity is encoded by the conformational dynamics of CK1, we performed a large set of independent molecular dynamics (MD) simulations of wildtype CK1 and the

Identifiers

PMID39896482
PMCPMC11785140

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.