Evidence map›Paper›PMID 39896461›Full record

ArticlebioRxiv : the preprint server for biology2025

Glo1 reduction in mice results in age- and sex-dependent metabolic dysfunction.

Ingrid Cely, Montgomery Blencowe, Le Shu, Graciel Diamante, In Sook Ahn, Guanglin Zhang, Jonnby LaGuardia, Ruoshui Liu, Zara Saleem, Susanna Wang and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Ingrid CelyDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.
Montgomery BlencoweDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0001-7147-1895
Le ShuDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.
Graciel DiamanteDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.
In Sook AhnDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.
Guanglin ZhangDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.
Jonnby LaGuardiaDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.
Ruoshui LiuDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.
Zara SaleemDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.
Susanna WangDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.
Richard DavisDepartments of Medicine, Human Genetics, and Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
Aldons J LusisDepartments of Medicine, Human Genetics, and Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
Xia YangDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.

Funding

Systems Genetics Dissection of Non-alcoholic SteatohepatitisR01DK117850 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Aldons Jake Lusis · 2019 to 2026
$4.6M
Systems genetics approach to inflammatory mechanisms in atherosclerosisR01HL147883 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LUSIS, ALDONS JAKE · 2019 to 2022
$3.0M
DHA Reverses Gene Network Signatures of Fructose-induced Metabolic SyndromeR01DK104363 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YANG, XIA · 2015 to 2019
$2.4M
NHLBI NIH HHS R01 HL147883NIDDK NIH HHS R01 DK104363NIDDK NIH HHS R01 DK117850
6 · The paper itself

Abstract

Objectives: Advanced glycation end products (AGEs) have been implicated as an important mediator of metabolic disorders including obesity, insulin resistance, and coronary artery disease. Glyoxalase 1 (Glo1) is a critical enzyme in the clearance of toxic dicarbonyl such as methylglyoxal, precursors of AGEs. The role of AGE-independent mechanisms that underly Glo1-induced metabolic disorders have yet to be elucidated. Methods: We performed a longitudinal study of female and male Results: Partial loss of Conclusions: Our results indicate that Glo1 reduction perturbs metabolic health and metabolic pathways in a sex- and age-dependent manner without significant changes in AGEs across metabolic tissues. Rather, tissue-specific gene expression analysis suggests that key transcription factors such as Hfn4a and Arntl as well as metabolite changes from alternative methylglyoxal detoxification such as pyruvate, likely contribute to metabolic dysregulation in

Indexed as

Advanced glycation endproductsGlucose dysregulationGlyoxalase 1Metabolic syndromeObesitySex difference

Identifiers

PMID39896461
PMCPMC11785252

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.