Evidence map›Paper›PMID 39896450›Full record

ArticlebioRxiv : the preprint server for biology2025

Old World alphaviruses use distinct mechanisms to infect brain microvascular endothelial cells for neuroinvasion.

Pablo A Alvarez, Ashley Tang, Declan M Winters, Prashant Kaushal, Angelica Medina, Karolina E Kaczor-Urbanowicz, Bryan Ramirez Reyes, Robyn M Kaake, Oliver I Fregoso, April D Pyle and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Pablo A AlvarezDepartment of Microbiology, Immunology, & Molecular Genetics, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0002-0079-3392
Ashley TangDepartment of Microbiology, Immunology, & Molecular Genetics, University of California, Los Angeles, CA 90095, USA.
Declan M WintersDepartment of Microbiology, Immunology, & Molecular Genetics, University of California, Los Angeles, CA 90095, USA.
Prashant KaushalDepartment of Microbiology, Immunology, & Molecular Genetics, University of California, Los Angeles, CA 90095, USA.
Angelica MedinaDepartment of Biological Science, Florida State University, Tallahassee, FL 32306, USA.
Karolina E Kaczor-UrbanowiczInstitute for Quantitative and Computational Biosciences, University of California, Los Angeles, CA 90095, USA.
Bryan Ramirez ReyesMolecular Biology Institute, University of California, Los Angeles, CA 90095, USA.
Robyn M KaakeDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94158, USA.
Oliver I FregosoDepartment of Microbiology, Immunology, & Molecular Genetics, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0003-3087-3374
April D PyleDepartment of Microbiology, Immunology, & Molecular Genetics, University of California, Los Angeles, CA 90095, USA.
Mehdi BouhaddouDepartment of Microbiology, Immunology, & Molecular Genetics, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0002-9526-1427
Hengli TangDepartment of Biological Science, Florida State University, Tallahassee, FL 32306, USA.ORCID 0000-0002-9358-410X
Melody M H LiDepartment of Microbiology, Immunology, & Molecular Genetics, University of California, Los Angeles, CA 90095, USA.

Funding

MULTIDISCIPLINARY TRAINING IN MICROBIAL PATHOGENESIST32AI007323 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Peter John Bradley · 1988 to 2026
$8.6M
Unraveling alphavirus neuroinvasion: Molecular insights from a stem cell based blood-brain barrier modelF31AI179235 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ALVAREZ, PABLO · 2024 to 2025
$68k
NIAID NIH HHS F31 AI179235NIAID NIH HHS T32 AI007323
6 · The paper itself

Abstract

Several alphaviruses bypass the blood-brain barrier (BBB), causing debilitating or fatal encephalitis. Sindbis virus (SINV) has been extensively studied

Identifiers

PMID39896450
PMCPMC11785202

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.