ArticleFrontiers in neuroscience2025
Impairment of neuronal activity in the dorsolateral prefrontal cortex occurs early in parkinsonism.
Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mapping the research landscape of Mild Cognitive Impairment in Parkinson's disease: a bibliometric and visualization analysis.Frontiers in aging neuroscience · 2025Pooled it
- Deep learning-based cognitive impairment brain imaging analysis: New methods, new technologies, and new paradigms.Neural regeneration research · 2026Article
- Dual-task gait and gait-cognition coupling in patients with Parkinson's disease versus healthy older adults: moderation by cognitive status.Frontiers in aging neuroscience · 2026Article
- Parkinsonism disrupts the balance between excitatory and inhibitory activity within the primary motor cortex during movement.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Transcranial alternating current stimulation can disrupt or reestablish neural entrainment in parkinsonian motor cortex.Brain stimulationArticle
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7 authors.
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Abstract
Background: Parkinson's disease (PD) is often characterized by altered rates and patterns of neuronal activity in the sensorimotor regions of the basal ganglia thalamocortical network. Little is known, however, regarding how neuronal activity in the executive control network of the brain changes in the parkinsonian condition. Objective: Investigate the impact of parkinsonism on neuronal activity in the dorsolateral prefrontal cortex (DLPFC), a key region in executive control, during a go/nogo reaching task. Methods: Using a within-subject design, single and multi-unit neuronal activity was recorded in the DLPFC of a nonhuman primate ( Results: Coincident with development of mild parkinsonian motor signs, there was a marked reduction in the percentage of DLPFC cells with significant task-related firing rate modulation during go and nogo conditions. Conclusion: These results suggest that DLPFC dysfunction may occur early in parkinsonism and contribute to cognitive impairments and disrupted executive function often observed in PD patients.
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