Evidence map›Paper›PMID 39896291›Full record

ArticleMaterials today. Bio2025

Biphasic biomimetic scaffolds based on a regionally decalcified bone framework and pre-chondrogenic microspheres for osteochondral defect repair.

Zhuo Liang, Qingqing Pan, Fei Xue, Jingdi Zhang, Zhenlin Fan, Weiyun Wang, Xueqiang Guo, Zhuang Qian, Yaping Shen, Wenjuan Song and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Zhuo LiangClinical Medical Center of Tissue Engineering and Regeneration, The First Affiliated Hospital of Xinxiang Medical University, The Third Affiliated Hospital of Xinxiang Medical University, Institutes of Health Central Plain, Xinxiang Medical University, Xinxiang, 453003, China.
Qingqing PanClinical Medical Center of Tissue Engineering and Regeneration, The First Affiliated Hospital of Xinxiang Medical University, The Third Affiliated Hospital of Xinxiang Medical University, Institutes of Health Central Plain, Xinxiang Medical University, Xinxiang, 453003, China.
Fei XueClinical Medical Center of Tissue Engineering and Regeneration, The First Affiliated Hospital of Xinxiang Medical University, The Third Affiliated Hospital of Xinxiang Medical University, Institutes of Health Central Plain, Xinxiang Medical University, Xinxiang, 453003, China.
Jingdi ZhangClinical Medical Center of Tissue Engineering and Regeneration, The First Affiliated Hospital of Xinxiang Medical University, The Third Affiliated Hospital of Xinxiang Medical University, Institutes of Health Central Plain, Xinxiang Medical University, Xinxiang, 453003, China.
Zhenlin FanClinical Medical Center of Tissue Engineering and Regeneration, The First Affiliated Hospital of Xinxiang Medical University, The Third Affiliated Hospital of Xinxiang Medical University, Institutes of Health Central Plain, Xinxiang Medical University, Xinxiang, 453003, China.
Weiyun WangClinical Medical Center of Tissue Engineering and Regeneration, The First Affiliated Hospital of Xinxiang Medical University, The Third Affiliated Hospital of Xinxiang Medical University, Institutes of Health Central Plain, Xinxiang Medical University, Xinxiang, 453003, China.
Xueqiang GuoClinical Medical Center of Tissue Engineering and Regeneration, The First Affiliated Hospital of Xinxiang Medical University, The Third Affiliated Hospital of Xinxiang Medical University, Institutes of Health Central Plain, Xinxiang Medical University, Xinxiang, 453003, China.
Zhuang QianClinical Medical Center of Tissue Engineering and Regeneration, The First Affiliated Hospital of Xinxiang Medical University, The Third Affiliated Hospital of Xinxiang Medical University, Institutes of Health Central Plain, Xinxiang Medical University, Xinxiang, 453003, China.
Yaping ShenClinical Medical Center of Tissue Engineering and Regeneration, The First Affiliated Hospital of Xinxiang Medical University, The Third Affiliated Hospital of Xinxiang Medical University, Institutes of Health Central Plain, Xinxiang Medical University, Xinxiang, 453003, China.
Wenjuan SongClinical Medical Center of Tissue Engineering and Regeneration, The First Affiliated Hospital of Xinxiang Medical University, The Third Affiliated Hospital of Xinxiang Medical University, Institutes of Health Central Plain, Xinxiang Medical University, Xinxiang, 453003, China.
Lei WangClinical Medical Center of Tissue Engineering and Regeneration, The First Affiliated Hospital of Xinxiang Medical University, The Third Affiliated Hospital of Xinxiang Medical University, Institutes of Health Central Plain, Xinxiang Medical University, Xinxiang, 453003, China.
Guangdong ZhouDepartment of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai Key Laboratory of Tissue Engineering, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
Yong HeThe Second Affiliated Hospital of Zhejiang University and Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province, School of Mechanical Engineering, Zhejiang University, Hangzhou, 310027, China.
Wenjie RenClinical Medical Center of Tissue Engineering and Regeneration, The First Affiliated Hospital of Xinxiang Medical University, The Third Affiliated Hospital of Xinxiang Medical University, Institutes of Health Central Plain, Xinxiang Medical University, Xinxiang, 453003, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteochondral defects are still facing a significant challenge in clinical surgery, making post-trauma repair difficult. Tissue engineering has provided a promising approach to solving these defects. However, existing scaffolds cannot replicate the complex biphasic cartilage-bone microenvironment with accuracy. We aimed to develop a biphasic biomimetic scaffold with regionally regulated vascularization that promoted chondrogenesis and osteogenesis through bidirectional regulation of endochondral ossification. This scaffold consisted of pre-chondrogenic microspheres (PCMs) and a decalcified bone frame prepared by decalcifying the cartilage layer and bone layer of the scaffold to varying degrees. Incorporation of PCMs into the cartilage layer created a microenvironment that promoted cartilage regeneration while axitinib was modified to inhibit vascularization and enhance cartilage regeneration. The bone layer provided a microenvironment that promoted endochondral ossification and facilitated bone repair.

Indexed as

AxitinibBiphasic biomimetic scaffoldsEndochondral ossificationOsteochondral repairPre-chondrogenic microspheres

Identifiers

PMID39896291
PMCPMC11783122

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.