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ArticleSovremennye tekhnologii v meditsine2024

Total Pancreatectomy with Islet Autotransplantation (TPIAT) as a Technique to Treat Chronic Idiopathic Pancreatitis: Early Experience Analysis.

V E Zagainov, D M Kuchin, A V Kashina, L A Lugovaya, N V Zarechnova, T A Galanina, N U Naraliev, Y I Kolesnik, E A Vasilchikova, P S Ermakova and 5 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Sovremennye tekhnologii v meditsine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

V E ZagainovMD, DSc, Director of the Institute of Surgery and Oncology; Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, Nizhny Novgorod, 603005, Russia; Head of the Department of Faculty Surgery and Transplantology; Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, Nizhny Novgorod, 603005, Russia; Deputy Chief Physician for Science and Innovation; Nizhny Novgorod Regional Oncologic Dispensary, 11/1 Delovaya St., Nizhny Novgorod, 603093, Russia.
D M KuchinMD, PhD, Associate Professor, Department of Faculty Surgery and Transplantology; Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, Nizhny Novgorod, 603005, Russia; Head of the Center for Abdominal Surgery; Nizhny Novgorod Regional Clinical Hospital named after N.A. Semashko, 190 Rodionova St., Nizhny Novgorod, 603093, Russia.
A V KashinaPhD, Head of the Regenerative Medicine Laboratory, Research Institute of Experimental Oncology and Biomedical Technologies; Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, Nizhny Novgorod, 603005, Russia.
L A LugovayaMD, PhD, Associate Professor, Department of Endocrinology and Internal Medicine; Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, Nizhny Novgorod, 603005, Russia.
N V ZarechnovaMD, PhD, Head of the Anesthesiology and Resuscitation Center; Nizhny Novgorod Regional Oncologic Dispensary, 11/1 Delovaya St., Nizhny Novgorod, 603093, Russia; Assistant, Department of Anesthesiology, Resuscitation and Transfusiology; Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, Nizhny Novgorod, 603005, Russia.
T A GalaninaHead of the Department of Resuscitation and Intensive Care for Patients with Combined Trauma; Nizhny Novgorod Regional Clinical Hospital named after N.A. Semashko, 190 Rodionova St., Nizhny Novgorod, 603093, Russia.
N U NaralievAssistant, Department of Faculty Surgery and Transplantology; Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, Nizhny Novgorod, 603005, Russia.
Y I KolesnikAssistant, Department of Faculty Surgery and Transplantology; Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, Nizhny Novgorod, 603005, Russia.
E A VasilchikovaLaboratory Assistant, Regenerative Medicine Laboratory, Research Institute of Experimental Oncology and Biomedical Technologies; Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, Nizhny Novgorod, 603005, Russia.
P S ErmakovaLaboratory Assistant, Regenerative Medicine Laboratory, Research Institute of Experimental Oncology and Biomedical Technologies; Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, Nizhny Novgorod, 603005, Russia.
E M ZagaynovSpecialist in X-ray Endovascular Diagnostics and Treatment, Clinical Hospital No.1; Privolzhsky District Medical Center of Federal Medico-Biologic Agency of Russia, 14 Ilyinskaya St., Nizhny Novgorod, 603109, Russia.
Yu A KucheryavyMD, PhD, Associate Professor, Head of the Gastroenterology Department; Ilyinskaya Hospital, M-9, 26th km, Krasnogorsk, Moscow Region, 143421, Russia.
A Yu BogomolovaLaboratory Assistant, Regenerative Medicine Laboratory, Research Institute of Experimental Oncology and Biomedical Technologies; Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, Nizhny Novgorod, 603005, Russia.
A L PotapovLaboratory Assistant, Optical Coherence Tomography Laboratory, Research Institute of Experimental Oncology and Biomedical Technologies; Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, Nizhny Novgorod, 603005, Russia.
I Yu ShirokovaPhD, Head of the Laboratory Research Department, Research Institute of Preventive Medicine; Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, Nizhny Novgorod, 603005, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic pancreatitis (CP) is a quite common disease with an annual incidence of up to 30 new cases per 100,000 persons in Russia, and 9.6 cases per 100,000 persons abroad. Idiopathic pancreatitis associated with genetic mutations ranks second in frequency. When conservative therapy is ineffective, surgical intervention is considered. Total pancreatectomy reduces pain, but leads to pancreatogenic diabetes mellitus. In case of hereditary pancreatitis caused by mutations in the Materials and Methods: Two patients with chronic pain pancreatitis with the Results: Following total pancreatoduodenectomy and autotransplantation, a significant decrease in pain and an improvement in quality of life were noted. Transplanted islets' function was reduced, due to their insufficient number, which required administration of exogenous insulin. Conclusion: The described experience demonstrates the TPIAT effectiveness in treatment of chronic pancreatitis, which can become a basis for further research and introduction of the technique into domestic clinical practice.

Indexed as

Islets of Langerhans TransplantationPancreatectomyPancreatitis, ChronicTransplantation, AutologousAdultCarrier ProteinsFemaleHumansMutationQuality of LifeTrypsinTrypsin Inhibitor, Kazal PancreaticYoung AdultCarrier ProteinsPRSS1 protein, humanSPINK1 protein, humanTrypsinTrypsin Inhibitor, Kazal Pancreaticchronic pancreatitisislets of Langerhanspancreaspancreatectomypancreatogenic diabetesthe SPINK1 and PRSS1 gene mutations

Identifiers

PMID39896151
PMCPMC11780585

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