Evidence map›Paper›PMID 39896137›Full record

ArticleFrontiers in chemistry2024

Sunday Amos Onikanni, Adewale Oluwaseun Fadaka, Tran Nhat Phong Dao, Valens Munyembaraga, Vincent Nyau, Nicole Remaliah Samantha Sibuyi, Morenike Grace Ajayi, Nguyen Thi Ai Nhung, Emmanuel Ejiofor, Basiru Olaitan Ajiboye and 2 more

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In one paragraph

Article in Frontiers in chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sunday Amos OnikanniCollege of Medicine, Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.
Adewale Oluwaseun FadakaDepartment of Biotechnology, University of the Western Cape, Bellville, South Africa.
Tran Nhat Phong DaoGraduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan.
Valens MunyembaragaInstitute of Translational Medicine and New Drug Development, College of Medicine, China Medical University, Taichung, Taiwan.
Vincent NyauDepartment of Food Science and Nutrition, School of Agricultural Sciences, University of Zambia, Lusaka, Zambia.
Nicole Remaliah Samantha SibuyiDepartment of Science and Innovation/Mintek Nanotechnology Innovation Centre, Biolabels Node, University of the Western Cape, Bellville, South Africa.
Morenike Grace AjayiDepartment of Chemical Sciences, Bamidele Olumilua University of Education, Science and Technology, Ikere, Nigeria.
Nguyen Thi Ai NhungDepartment of Chemistry, University of Sciences, Hue University, Hue, Vietnam.
Emmanuel EjioforDepartment of Chemical Sciences, Faculty of Science, Clifford University, Owerrinta, Nigeria.
Basiru Olaitan AjiboyePhytomedicine and Molecular Toxicology Research Laboratory, Department of Biochemistry, Federal University Oye Ekiti, Oye Ekiti, Nigeria.
Minh Hoang LeFaculty of Traditional Medicine, Can Tho University of Medicine and Pharmacy, Can Tho, Vietnam.
Hen-Hong ChangGraduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Severe protein clumping in the lens can block light and lead to vision issues in cataract patients. Recent studies have linked β-crystallins, which are key proteins in the lens, to the development of cataracts. Specifically, the S175G/H181Q mutation in the βB2-crystallin gene plays a major role in cataract formation. Methods: To understand how this mutation can be activated, we utilized computational methods to predict activators from Phaseolus vulgaris. The Schrödinger platform was employed to screen bioactive compounds and simulate molecular interactions in order to analyze binding and structural changes. Results: Our results indicated that these phytochemicals are stable near S175G/H181Q. Discussion: These findings suggest novel approaches that could potentially be developed into effective anticataract medications through further refinement and additional testing, ultimately resulting in the creation of more potent agents for cataract treatment.

Indexed as

cataractconformationPhaseolus vulgarisSchrödingerβB2-crystallin

Identifiers

PMID39896137
PMCPMC11782562

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.