Evidence map›Paper›PMID 39896077›Full record

ReviewFrontiers in pharmacology2025

The role of multiomics in revealing the mechanism of skin repair and regeneration.

Shaoyan Shi, Xuehai Ou, Jafeng Long, Xiqin Lu, Siqi Xu, Gang Li

Abstract readReview
In one paragraph

Review in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shaoyan ShiDepartment of Hand Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi an, China.
Xuehai OuDepartment of Hand Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi an, China.
Jafeng LongDepartment of Hand Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi an, China.
Xiqin LuDepartment of Hand Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi an, China.
Siqi XuDepartment of Hand Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi an, China.
Gang LiDepartment of Hand Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi an, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Skin repair and regeneration are crucial processes in restoring the integrity of the skin after injury, with significant implications for medical treatments and plastic surgery. Multiomics, an integrated approach combining genomics, transcriptomics, proteomics, and metabolomics, offers unprecedented insights into the complex molecular and cellular mechanisms involved in skin healing. This review explores the transformative role of multiomics in elucidating the mechanisms of skin repair and regeneration. While genomic studies identify the genetic basis of wound healing, transcriptomics and proteomics uncover the dynamic changes in gene and protein expression, and metabolomics provides a snapshot of metabolic alterations associated with wound healing. Integrative multiomics studies can also identify novel biomarkers and therapeutic targets for skin regeneration. Despite the technical and biological challenges, the future of multiomics in skin research holds great promise for advancing personalized medicine and improving wound healing strategies. Through interdisciplinary collaboration, multiomics has the potential to revolutionize our understanding of skin repair, paving the way for innovative treatments in plastic surgery and beyond.

Indexed as

immunemultiomicsplastic surgeryskin regenerationskin repair

Identifiers

PMID39896077
PMCPMC11782119

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.