ArticleJournal of Cancer2025
Integrating of Radiomics and Single-cell Transcriptomics Uncovers the Crucial Role of γδ T Cells in Lung Adenocarcinoma.
Article in Journal of Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Interleukin-1 receptor-associated kinase 1 controls chemoresistance and immuno-killing in non-small cell lung cancer.Signal transduction and targeted therapy · 2026Article
- Review
- A macro-micro-macro radiogenomic framework identifies FIBCD1 as a key immune-modulating biomarker in breast cancer.Journal of translational medicine · 2025Article
- Multi-scale data reveal a CD24(+) MUCL1(+) tumor subgroup associated with unfavorable prognosis in ER+ breast cancer.Frontiers in immunology · 2025Article
- Multiomics profiling identifies the poor prognostic role of a tumor cluster with GNA15 overexpression in triple-negative breast cancer.Frontiers in immunology · 2025Article
- Integrating Bulk RNA Sequencing and CRISPR-Cas9 Screening to Identify Proliferation-Related Genes for Prognostic Stratification in Breast Cancer.Journal of Cancer · 2025Article
- Integration of Multi-Scale Profiling and Machine Learning Reveals the Prognostic Role of Extracellular Matrix-Related Cancer-Associated Fibroblasts in Lung Adenocarcinoma.International journal of medical sciences · 2025Article
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Authors and funding
9 authors.
Funding
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Abstract
Gamma-delta (γδ) T cells are a crucial component of the tumor immune microenvironment which are considered a promising potential therapeutic strategy and target. Increasing evidence suggests that these unique immune cells play significant roles across various cancers. However, γδ T cells are often regarded as having dual roles in tumors, and their influence on lung adenocarcinoma (LUAD) remains controversial. In this research, we employed a wild-ranging approach using multi-omics data to investigate the function of γδ T cells in LUAD. The abundance of γδ T cell infiltration is linked to a positive prognosis in lung adenocarcinoma. The tumor-inhibiting role of γδ T cells was played through intrinsic lineage evolution, acquiring cytotoxic functions and engaging in signal transduction with antigen-presenting cells. Furthermore, patients with higher γδ T cells infiltration abundance might be more favorable for immunotherapy. Lastly, we established a predictive model using CT images based on radiomics, providing a non-invasive strategy to assess γδ T cells infiltration in LUAD patients. These findings offer new insights and perspectives the personalized therapies of γδ T cells.
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