ArticleAllergy, asthma & immunology research2025
Genome-Wide Identification and Comparative Analysis of Allergens in
Article in Allergy, asthma & immunology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Critical Knowledge Gaps for Shellfish Allergies: Insights from Global Market Presence and Trade of Shellfish.Foods (Basel, Switzerland) · 2026Review
- Multi-Omic Analysis of Scylla serrata Reveals the Allergen Landscape of Mud Crabs and Decapoda Species.Allergy · 2026Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeCrustacean shellfish is one of the eight most common food allergens, and crayfish is a highly valued shellfish species for consumption in China. However, the detailed allergen profile of crayfish remains unknown, with only four allergen groups reported in the WHO/IUIS allergen nomenclature database. In this study we aimed to identify novel allergens based on the
methodsWe assembled the crayfish genome using both long-read and short-read sequencing data and identified putative allergens using the BLAST algorithm based on sequence homology. We employed bioinformatics tools to investigate the expression levels, gene structure, and synteny of these putative allergens. We also applied indirect enzyme-linked immunosorbent assay by using patients' sera to determine allergenicity and utilized proteomic methods to identify novel allergens.
resultsWe identified a total of 11 putative allergen groups, including all isoforms or homologs for each allergen group based on the genome and three putative allergens by using 2-dimensional (2D) mass spectrometry. We identified 2 novel allergens, pPro c 3.0301 and pPro c 6.0201, with immunoglobulin E reactivity of 33.3% and 20%, respectively.
conclusionsBy providing a comprehensive understanding of the complete allergen profile, our study presents a foundation for comprehending
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