ArticleAllergy, asthma & immunology research2025
Longitudinal Trajectories of Asthma and Allergic Comorbidities in the Korean Childhood Asthma Study.
Article in Allergy, asthma & immunology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Uncontrolled Status, Disease Burden, and Associated Risk Factors Among Patients with Asthma Receiving Medium-to-High Dose ICS or ICS/LABA: A Retrospective Analysis.Advances in therapy · 2026Observational
- Variations in Healthcare Provider Interactions and Treatment Satisfaction by Patient Race and Ethnicity: A Survey of Adults with Atopic Dermatitis.Advances in therapy · 2026Article
- Baseline Characteristics of Patients with Asthma Initiating Dupilumab in a Real-World Setting: The REVEAL Registry.Advances in therapy · 2026Observational
- Advances in clinical examination techniques for allergic rhinitis: a review from traditional testing to precision diagnosis.Frontiers in allergy · 2026Review
- Comparative Analysis of Outcomes of Influenza and COVID-19 Admissions Among Children With Asthma: A Nationwide Retrospective Cohort Study Using the US National Readmissions Database.JMIR medical informatics · 2025Article
- Navigating the Asthma Maze in Children Through Trajectories With Allergic Comorbidities.Allergy, asthma & immunology research · 2025Article
- Classification and Hemodynamic Characteristics of Uterine Artery Blood Flow in Recurrent Spontaneous Abortion.Current medical imaging · 2025Article
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25 authors.
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Abstract
purposeStudies on the longitudinal clinical features of asthma or allergic comorbidities in children are limited. We aimed to examine the trajectories of asthma and allergic comorbidities and determine whether these trajectories differ according to clinical asthma phenotypes from birth to adolescence.
methodsWe enrolled 958 children with physician-diagnosed asthma from the Korean childhood Asthma Study (KAS) cohort. Children with asthma were classified using hierarchical cluster analysis. Information on the diagnosis and treatment of allergic diseases before cohort entry was collected through linkage with national claims data from the Health Insurance Review and Assessment Service.
resultsIn the KAS cohort, approximately half had a history of atopic dermatitis (AD) before infancy, with its prevalence gradually decreasing during adolescence. The prevalence of allergic rhinitis (AR) increased with age. The prevalence of asthma increased during early childhood and decreased during adolescence. According to the natural progression of asthma, AD, and AR trajectories, 4 distinctive phenotypes were identified using latent class analysis: "almost controlled," "early-onset asthma with AD and late-onset AR," "early-onset asthma only," and "intermediate-onset asthma and late-onset AR." Four distinct clinical trajectory patterns of asthma, AD, and AR were identified among the 4 cluster phenotypes based on baseline characteristics. Cluster 1 comprised male-dominant, atopic asthma with early-onset AD and late-onset AR. Cluster 2 included early-onset, atopic asthma with AD" persistent into adolescence. Cluster 3 encompassed "puberty-onset, female-dominant atopic asthma" with early-onset and low remission rates. Cluster 4 comprised "early-onset asthma with less atopic features" and the lowest comorbidities of AD and AR.
conclusionsThe longitudinal trajectories of asthma and allergic comorbidities in Korean children can be classified into distinct clusters. Most phenotypes exhibited early-onset asthma with a varying prevalence of comorbidities. The persistence of AD, rather than its onset age, determines the phenotype.
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