Evidence map›Paper›PMID 39895575›Full record

ArticleFEBS open bio2025

HDAC4 regulates apoptosis in Acan-Cre

Jingrui Huang, Yukun Xu, Yujia Li, Yiming Pang, Xueting Ding, Raorao Zhou, Dan Liang, Xianda Che, Yuanyu Zhang, Chunfang Wang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS open bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jingrui HuangShanxi Key Laboratory of Bone and Soft Tissue Injury Repair, Department of Orthopedics, Second Hospital of Shanxi Medical University, Taiyuan, China.ORCID https://orcid.org/0009-0001-9792-7595
Yukun XuShanxi Key Laboratory of Bone and Soft Tissue Injury Repair, Department of Orthopedics, Second Hospital of Shanxi Medical University, Taiyuan, China.
Yujia LiShanxi Key Laboratory of Bone and Soft Tissue Injury Repair, Department of Orthopedics, Second Hospital of Shanxi Medical University, Taiyuan, China.
Yiming PangShanxi Key Laboratory of Bone and Soft Tissue Injury Repair, Department of Orthopedics, Second Hospital of Shanxi Medical University, Taiyuan, China.
Xueting DingShanxi Key Laboratory of Bone and Soft Tissue Injury Repair, Department of Orthopedics, Second Hospital of Shanxi Medical University, Taiyuan, China.
Raorao ZhouShanxi Key Laboratory of Bone and Soft Tissue Injury Repair, Department of Orthopedics, Second Hospital of Shanxi Medical University, Taiyuan, China.
Dan LiangShanxi Key Laboratory of Bone and Soft Tissue Injury Repair, Department of Orthopedics, Second Hospital of Shanxi Medical University, Taiyuan, China.
Xianda CheShanxi Key Laboratory of Bone and Soft Tissue Injury Repair, Department of Orthopedics, Second Hospital of Shanxi Medical University, Taiyuan, China.
Yuanyu ZhangShanxi Key Laboratory of Bone and Soft Tissue Injury Repair, Department of Orthopedics, Second Hospital of Shanxi Medical University, Taiyuan, China.
Chunfang WangDepartment of Embryology, School of Basic Medical Sciences, Shanxi Medical University, Taiyuan, China.
Wenjin LiDepartment of Stomatology, Second Hospital of Shanxi Medical University, Taiyuan, China.
Pengcui LiShanxi Key Laboratory of Bone and Soft Tissue Injury Repair, Department of Orthopedics, Second Hospital of Shanxi Medical University, Taiyuan, China.ORCID https://orcid.org/0000-0002-0414-236X

Funding

Key Research and Development Project of Shanxi Province 'Intelligent Research and Application of Gait Analysis in Locomotor Injury Diseases Based on Big Data Platform' 202202150401019Research Grant Program for Returned Scholars of Shanxi Province 2022-199Shanxi Province Higher Education 'Billion Project' Science and Technology Guidance Project BYGL013
6 · The paper itself

Abstract

Several studies have previously shown that histone deacetylase 4 (HDAC4) can regulate endoplasmic reticulum stress-induced apoptosis through the activating transcription factor 4 (ATF4)/CAAT/enhancer binding protein homologous (CHOP) signaling pathway, thereby affecting the progression of osteoarthritis (OA). The present study investigated the regulatory mechanism of HDAC4 in chondrocyte apoptosis in OA using Acan-Cre

Indexed as

Activating Transcription Factor 4ApoptosisHistone DeacetylasesOsteoarthritisRepressor ProteinsAnimalsChondrocytesDisease Models, AnimalDown-RegulationEndoplasmic Reticulum StressMaleMiceMice, KnockoutSignal TransductionTranscription Factor CHOPActivating Transcription Factor 4Atf4 protein, mouseHdac5 protein, mouseHistone DeacetylasesRepressor ProteinsTranscription Factor CHOPapoptosisATF4/CHOP signaling pathwayHDAC4osteoarthritistransgenic mouse

Identifiers

PMID39895575
PMCPMC12051021

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.