ArticleJournal of clinical laboratory analysis2025
Comparison of Urinary Red Blood Cell Distribution (URD) and Dysmorphic Red Blood Cells for Detecting Glomerular Hematuria: A Multicenter Study.
Article in Journal of clinical laboratory analysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Deep Learning-Assisted Classification of Urinary Red Blood Cell Morphology for Glomerular Hematuria Screening: A Pilot Study.Journal of clinical laboratory analysis · 2026Article
- Machine Learning-Based Analysis of UF-5000 Scattergrams Improves the Identification of Urinary Dysmorphic Red Blood Cells.Annals of laboratory medicine · 2026Article
- Multicenter study of the diagnostic value of erythrocyte morphology assessment by the EH-2090 for differentiation of glomerular and non-glomerular hematuria.BMC nephrology · 2026Article
- Development of a Novel UPC (Urine Red Blood Cell Distribution, Proteinuria, and Serum Creatinine) Index to Differentiate Glomerular from Nonglomerular Hematuria.Journal of clinical laboratory analysis · 2026Article
- The Diagnostic Value of Cellular Phenotyping and Pathological Casts Using Urine Flow Cytometry in Children with Lupus Nephritis.Diseases (Basel, Switzerland) · 2026Article
- A non-invasive predictive model for identifying non-diabetic kidney disease in type 2 diabetes mellitus: development and multicenter validation.American journal of clinical and experimental urology · 2026Article
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Authors and funding
8 authors.
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Abstract
backgroundThe clinical utility of urinary red blood cell (RBC) distribution (URD) remains limited. This study aimed to compare the diagnostic performance of URD and dysmorphic RBC (dRBC) in a multicenter study.
methodsThis study enrolled 703 patients who visited four tertiary medical centers in Korea. Patients were classified into glomerular diseases with biopsy (N = 169), renal diseases including chronic kidney disease (N = 194), nephrotic syndrome (NS; N = 88), tubulointerstitial diseases (N = 36), acute kidney injury (N = 32), others (N = 10), and extrarenal diseases (N = 174). Renal parameters, urine microscopic examination, urinalysis, and URD assessments were conducted. The diagnostic performances of dRBC and URD were evaluated.
resultsMedian values of both dRBC and URD were significantly elevated in patients with glomerular diseases. URD exhibited a significant correlation with dRBC (r = 0.536) and albumin creatinine ratio (r = 0.186), while no significant correlation was observed with specific gravity (r = -0.03). Among renal diseases, dRBC and URD values were notably higher in patients with NS. The agreement rate between dRBC and URD results was 78.3% (112/143), with 31 instances showing discrepancies. ROC curve analysis comparing glomerular and extrarenal diseases yielded cutoff values of 18% for dRBC and 31.9% for URD, resulting in corresponding areas under the curve (AUC) of 0.79 and 0.83, respectively.
conclusionsURD exhibited a comparable diagnostic performance, as indicated by a similar AUC value to that of dRBC, while offering the added advantage of providing objective and standardizable results. This attribute enhances its utility as a parameter for distinguishing between patients with glomerular hematuria (GH) and those with non-GH.
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