ReviewJournal of the American Heart Association2025
Cerebral Blood Flow in Orthostatic Intolerance.
Review in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Association of rapamycin treatment with the modulation of purine metabolism, reduced microglial inflammatory responses, improved mitochondrial energy metabolism, and alleviation of fatigue symptoms in ME/CFS subjects: pilot findings from phase-II observational study.Journal of translational medicine · 2026Trial
- POTS: A neuroimmune disorder with cardiovascular manifestations?Heart rhythm O2 · 2026Article
- Review
- Rome was not built in a day, nor is a resilient clinical autonomic care unit.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026Article
- Review
- Stroke volume reduction impairs cerebrovascular regulation through ETCOClinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026Article
- Orthostatic blood pressure trajectories characterize heterogeneous disease progression in Parkinson's disease.Journal of neurology · 2026Article
- Unveiling orthostatic hypotension in precapillary pulmonary hypertension.ERJ open research · 2026Article
- Orthostatic cerebral hypoperfusion syndrome: an uncommon cause of orthostatic intolerance in a patient with COVID-19.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026Article
- The impact of posture changes on critical closing pressure and resistance-area product regulation in healthy subjects.European journal of applied physiology · 2026Article
- Prevalence of Central Sensitization in Postural Tachycardia Syndrome.JAMA network open · 2026Article
- Postural Orthostatic Tachycardia Syndrome, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Long COVID as Neuroimmune Disorders.ImmunoTargets and therapy · 2026Review
- Using Active Standing Orthostatic Stress Test to Assess Physiological Responses in Individuals with Long COVID: A Systematic Review.Journal of clinical medicine · 2025Review
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cerebral blood flow (CBF) is vital for delivering oxygen and nutrients to the brain. Many forms of orthostatic intolerance (OI) involve impaired regulation of CBF in the upright posture, which results in disabling symptoms that decrease quality of life. Because CBF is not easy to measure, rises in heart rate or drops in blood pressure are used as proxies for abnormal CBF. These result in diagnoses such as postural orthostatic tachycardia syndrome and orthostatic hypotension. However, in many other OI syndromes such as myalgic encephalomyelitis/chronic fatigue syndrome and long COVID, heart rate and blood pressure are frequently normal despite significant drops in CBF. This often leads to the incorrect conclusion that there is nothing hemodynamically abnormal in these patients and thus no explanation or treatment is needed. There is a need to measure CBF, as orthostatic hypoperfusion is the shared pathophysiology for all forms of OI. In this review, we examine the literature studying CBF dysfunction in various syndromes with OI and evaluate methods of measuring CBF including transcranial Doppler ultrasound, extracranial cerebral blood flow ultrasound, near infrared spectroscopy, and wearable devices.
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