Evidence map›Paper›PMID 39895531›Full record

Trial reportJournal of the American Heart Association2025

Sex Differences in Computed Tomography Coronary Stenosis Severity Versus Flow Impairment and Impact on Revascularization, Clinical Events and Health Care Costs: A FORECAST Substudy.

Lavinia Gabara, Jonathan Hinton, Mohamed Kira, James Shambrook, Ausami Abbas, Sam Wilding, Jonathon A Leipsic, Pamela S Douglas, Nick Curzen

Abstract readComparative StudyMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lavinia GabaraCoronary Research Group University Hospital Southampton NHS FT Southampton United Kingdom.ORCID 0000-0003-1729-3391
Jonathan HintonCoronary Research Group University Hospital Southampton NHS FT Southampton United Kingdom.ORCID 0000-0003-1670-5550
Mohamed KiraCoronary Research Group University Hospital Southampton NHS FT Southampton United Kingdom.
James ShambrookDepartment of Cardiothoracic Radiology, Wessex Cardiac Centre University Hospital Southampton Southampton United Kingdom.ORCID 0000-0002-3084-5106
Ausami AbbasDepartment of Cardiothoracic Radiology, Wessex Cardiac Centre University Hospital Southampton Southampton United Kingdom.
Sam WildingClinical Trials Unit University of Southampton United Kingdom.ORCID 0000-0003-4184-2821
Jonathon A LeipsicDepartment of Radiology and Centre for Heart Lung Innovation University of British Columbia and St. Paul's Hospital Vancouver British Columbia Canada.ORCID 0009-0002-3892-9029
Pamela S DouglasDivision of Cardiology, Department of Medicine Duke University Medical Centre, Duke Clinical Research Institute, Duke University School of Medicine Durham NC USA.ORCID 0000-0001-9876-4049
Nick CurzenCoronary Research Group University Hospital Southampton NHS FT Southampton United Kingdom.ORCID 0000-0001-9651-7829

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe impact of sex-related differences in coronary atheroma and flow impairment severity on clinical events and costs remains unclear. METHODS AND

resultsThis is a secondary analysis of patients with stable coronary artery disease who underwent both coronary computed tomography angiography  and fractional flow reserve derived from computed tomography as part of the FORECAST (Fractional Flow Reserve Derived From Computed Tomography Coronary Angiography in the Assessment and Management of Stable Chest Pain) trial, investigating (1) the relationship between coronary stenosis severity on coronary computed tomography angiography and fractional flow reserve derived from computed tomography FFR

conclusionsThere are significant sex differences in the anatomico-functional assessment of coronary artery disease leading to differences in clinical management, costs, and adverse events.

Indexed as

Computed Tomography AngiographyCoronary AngiographyCoronary Artery DiseaseCoronary StenosisCoronary VesselsFractional Flow Reserve, MyocardialHealth Care CostsMyocardial RevascularizationAgedFemaleHumansMaleMiddle AgedPredictive Value of TestsSeverity of Illness IndexSex Factorscoronary artery diseasecoronary computed tomography angiographyfractional flow reserve derived from computed tomographymajor adverse cardiovascular eventsrevascularizationrisk stratificationsex differences

Identifiers

PMID39895531
PMCPMC12074785

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.