ArticleCirculation. Arrhythmia and electrophysiology2025
Validation of a Demography-Based Adaptive QT Correction Formula Using Pediatric and Adult Datasets Acquired From Humans and Guinea Pigs.
Article in Circulation. Arrhythmia and electrophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- The isolated working guinea pig heart: A functional and electrophysiological characterisation.Experimental physiology · 2026Article
- Enhanced Demographically Adaptive QT Correction Improves Pediatric Screening for Congenital Long QT Syndrome.medRxiv : the preprint server for health sciences · 2026Article
- Age-dependent Dynamics of the Electrocardiographic Parameters in Cardiovascular Disease-Free Children.medRxiv : the preprint server for health sciences · 2026Article
- Chamber-specific transcriptomic insight into cardiac development using guinea pig and human heart tissue.Physiological genomics · 2026Article
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Abstract
backgroundQT correction (QTc) formulae are widely used in clinical and research settings but often underperform, possibly due to demographic influences on the QT-heart rate (HR) relationship. To address this limitation, we developed an adaptive QTc (QTcAd) formula, which adjusts for demographic factors like age, and compared its efficacy to other standard formulae.
methodsThe QTcAd formula was tested across diverse age groups with different HR in both humans and guinea pigs. Using retrospective ECG data from 1819 pediatric patients at Children's National Hospital and 2400 subjects from the Pediatric Heart Network database, alongside in vivo (N=55) and ex vivo (N=66) guinea pig ECG recordings, we evaluated the formula's effectiveness. Linear regression fit parameters of QTc-HR (slope and
resultsIn both human subjects and guinea pigs, the QTcAd formula (QTcAd=QT+(|
conclusionsThe demography-based QTcAd formula showed superior performance across human and guinea pig age groups, which may enhance the efficacy of rate-corrected K.M.M. for cardiovascular disease diagnosis, risk stratification, and drug safety testing in children and adults.
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