Characterization of c-Src During Listeria monocytogenes Cell-to-Cell Spreading.

Petra A McLeod, Aaron S Dhanda, Julian A Guttman

Abstract read

In one paragraph

Article in The Journal of infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Petra A McLeodDepartment of Biological Sciences, Centre for Cell Biology, Development, and Disease, Simon Fraser University, Burnaby, British Columbia, Canada.ORCID 0009-0007-2349-7039

Aaron S DhandaDepartment of Biological Sciences, Centre for Cell Biology, Development, and Disease, Simon Fraser University, Burnaby, British Columbia, Canada.

Julian A GuttmanDepartment of Biological Sciences, Centre for Cell Biology, Development, and Disease, Simon Fraser University, Burnaby, British Columbia, Canada.

Funding

CIHR 178189

6 · The paper itself

Abstract

Listeria monocytogenes replicates within host cells and spreads from cell to cell using actin-based motility. Cell-to-cell movement of L. monocytogenes is achieved by creating actin-rich membrane protrusions (listeriopods), which generate corresponding invaginations in adjacent cells through caveolin-mediated endocytosis. We show that c-Src, a multifunctional tyrosine kinase, is enriched at invaginations and is crucial for efficient cell-to-cell spreading of the bacteria as cells expressing c-Src mutants that were either constitutively active or those that impeded the function of c-Src resulted in significantly more (or less) cell-to-cell spreading. This work demonstrates the importance of c-Src in influencing L. monocytogenes' ability to spread intercellularly.

Indexed as

Listeria monocytogenesAnimalsEndocytosisHumanssrc-Family Kinasessrc-Family Kinasesbacterial disseminationendocytosishost-pathogen interactionsListeria monocytogenesSrc-dependent phosphorylation

Identifiers

PMID39895278

DOI10.1093/infdis/jiaf063

PMCPMC12128067

What OpenQuestion holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.