ArticleAnalytical chemistry2025
Automatically Signal-Enhanced Lateral Flow Immunoassay for Ultrasensitive Salivary Cortisol Detection.
Article in Analytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Dual-Channel Interdigitated Aptamer-Based Sensors for Rapid Small-Molecule Detection in Biofluids.Angewandte Chemie (International ed. in English) · 2026Article
- Extraoral Detection of Biomarkers and Pathogens in Saliva: Comprehensive, Panoramic Review.Biosensors · 2026Review
- Article
- Advancing Women's Performance in Fitness and Sports: An Exploratory Field Study on Hormonal Monitoring and Menstrual Cycle-Tailored Training Strategies.Sports (Basel, Switzerland) · 2026Article
- Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Competitive lateral flow immunoassay (LFI) is a commonly used platform for detecting cortisol and other small molecules. However, its low sensitivity is a critical limitation for application in point-of-care tests. Thus, various signal enhancement methods have been developed, requiring complex operational steps and specialized detectors. In this study, we propose an automatic signal-enhanced LFI (asLFI), providing 100 times improved colorimetric sensitivity by applying 10,000-fold fewer AuNP conjugates compared to conventional competitive LFI, involving a single operational step. The incorporation of fewer AuNP conjugates improves the sensitivity of competitive LFI but does not produce a visible signal spontaneously. asLFI facilitates automatic signal enhancement without requiring additional operational steps, affording visible colorimetric signals. asLFI demonstrated high sensitivity in detecting cortisol (limit of detection = 3.8 pg mL
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.