Evidence map›Paper›PMID 39895191›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2025

NIR-II Fluorescent Thermophoretic Nanomotors for Superficial Tumor Photothermal Therapy.

Jiwei Jiang, Jing Hu, Mingtong Li, Mingzhi Luo, Bin Dong, Metin Sitti, Xiaohui Yan

Abstract read
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. Article
  2. Programmable Organic APharmaceutics · 2026
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  6. Bandgap-Engineered PtAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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  20. PtTeMaterials today. Bio · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jiwei JiangInstitute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, 215123, China.
Jing HuState Key Laboratory of Vaccines for Infectious Diseases, Center for Molecular Imaging and Translational Medicine, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, 361005, China.
Mingtong LiPhysical Intelligence Department, Max Planck Institute for Intelligent Systems, 70569, Stuttgart, Germany.ORCID https://orcid.org/0000-0002-1685-6052
Mingzhi LuoChangzhou Key Laboratory of Respiratory Medical Engineering, Institute of Biomedical Engineering and Health Sciences, School of Medical and Health Engineering, Changzhou University, Changzhou, Jiangsu, 213164, China.
Bin DongInstitute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, 215123, China.
Metin SittiPhysical Intelligence Department, Max Planck Institute for Intelligent Systems, 70569, Stuttgart, Germany.ORCID https://orcid.org/0000-0001-8249-3854
Xiaohui YanState Key Laboratory of Vaccines for Infectious Diseases, Center for Molecular Imaging and Translational Medicine, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, 361005, China.

Funding

Collaborative Innovation Center of Suzhou Nano Science & TechnologyDoctoral Scientific Research Foundation of Suzhou University 2021BSK008Fund for Excellent Creative Research Teams of Jiangsu Higher Education Institutions and the Suzhou Key Laboratory of Surface and Interface Intelligent Matter SZS2022011Joint International Research Laboratory of Carbon-Based Functional Materials and DevicesMax-Planck-GesellschaftNational Key Research and Development Program of China 2018YFE0306105National Natural Science Foundation of China 22173068National Natural Science Foundation of China 82001845Natural Science Foundation of Anhui Province 2108085MB67Natural Science Research Key Project of the Education Department of Anhui Province 2022AH051377Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)Scientific Research Foundation of State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory 2023XAKJ0101001Suzhou Key Laboratory of Functional Nano & Soft MaterialsSuzhou University Research Platform 2021XJPT06
6 · The paper itself

Abstract

Peritumoral subcutaneous injection has been highly envisioned as an efficient yet low-risk administration of photothermal agents for superficial tumor photothermal therapy. However, obstructed by complex subcutaneous tissue, the delivery of injected photothermal agents to the specific tumor remains a critical issue. Herein, the study reports a polydopamine (PDA)-encapsulated spherical core/shell nanomotor with fluorescent indocyanine green (ICG) immobilized on its PDA shell. Upon the first near-infrared (NIR-I) irradiation, this motor can generate favorable photothermal heat, and meantime, emit a robust ICG fluorescence in the second near-infrared window (NIR-II). The heat turns the motor into an active photothermal agent able to perform thermophoretic propulsion along the irradiation direction in subcutaneous tissue, while the ICG fluorescence can direct the subcutaneous propulsion of motors toward specific tumor through real-time NIR-II imaging. These functions endow the motor with the ability of moving to tumor after being injected at peritumoral site, enabling an enhanced photothermal therapy (PTT). The results demonstrated herein suggest an integrated nanorobotic tool for the superficial PTT using peritumoral administration, highlighting an NIR-II imaging-directed subcutaneous propulsion.

Indexed as

Fluorescent DyesNanoparticlesNeoplasmsPhotothermal TherapyAnimalsCell Line, TumorHumansIndocyanine GreenIndolesInfrared RaysMiceOptical ImagingPolymersFluorescent DyesIndocyanine GreenIndolespolydopaminePolymersmicro‐/nanomotorsNIR‐II imagingperitumoral administrationphotothermal therapysubcutaneous delivery

Identifiers

PMID39895191
PMCPMC11899490

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.