Evidence map›Paper›PMID 39895136›Full record

ArticleACS applied bio materials2025

Anti-Infective Bacteriophage Immobilized Nitric Oxide-Releasing Surface for Prevention of Thrombosis and Device-Associated Infections.

Vijay Singh Gondil, Morgan Ashcraft, Sama Ghalei, Anil Kumar, Sarah N Wilson, Ryan Devine, Hitesh Handa, Elizabeth J Brisbois

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied bio materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Vijay Singh GondilSchool of Chemical, Materials and Biomedical Engineering, College of Engineering, University of Georgia, Athens, Georgia 30602, United States.
Morgan AshcraftPharmaceutical and Biomedical Sciences Department, College of Pharmacy, University of Georgia, Athens, Georgia 30602, United States.
Sama GhaleiSchool of Chemical, Materials and Biomedical Engineering, College of Engineering, University of Georgia, Athens, Georgia 30602, United States.
Anil KumarSchool of Chemical, Materials and Biomedical Engineering, College of Engineering, University of Georgia, Athens, Georgia 30602, United States.
Sarah N WilsonSchool of Chemical, Materials and Biomedical Engineering, College of Engineering, University of Georgia, Athens, Georgia 30602, United States.
Ryan DevineSchool of Chemical, Materials and Biomedical Engineering, College of Engineering, University of Georgia, Athens, Georgia 30602, United States.
Hitesh HandaSchool of Chemical, Materials and Biomedical Engineering, College of Engineering, University of Georgia, Athens, Georgia 30602, United States.ORCID 0000-0002-9369-7374
Elizabeth J BrisboisSchool of Chemical, Materials and Biomedical Engineering, College of Engineering, University of Georgia, Athens, Georgia 30602, United States.ORCID 0000-0002-9283-5448

Funding

Nitric Oxide Functionalized Antibiotics to Combat Infections and Thrombosis for Extracorporeal Life SupportR01HL172496 · NHLBI · UNIVERSITY OF GEORGIA · PI Elizabeth Joy Brisbois, Hitesh Handa · 2024 to 2026
$1.5M
NHLBI NIH HHS R01 HL172496
6 · The paper itself

Abstract

The treatment of critically ill patients has made great strides in the past few decades due to the rapid development of indwelling medical devices. Despite immense advancements in the design of these devices, indwelling medical device-associated infections and thrombosis are two major clinical problems that may lead to device failure and compromise clinical outcomes. Antibiotics are the current treatment choice for these infections; however, the global emergence of antibiotic-resistance and their biofilm formation abilities complicate the management of such infections. Moreover, systemic administration of anticoagulants has been used to counter medical device-induced thrombosis, but a range of serious adverse effects associated with all types of available anticoagulants entails exploring alternative options to counter device-associated thrombosis. In this study, bacteriophages (phages) were covalently immobilized on polydimethylsiloxane (PDMS) surface containing the nitric oxide (NO) donor

Indexed as

Anti-Bacterial AgentsBacteriophagesBiocompatible MaterialsNitric OxideThrombosisDimethylpolysiloxanesEscherichia coliHumansMaterials TestingMicrobial Sensitivity TestsParticle SizeS-Nitroso-N-AcetylpenicillamineSurface PropertiesAnti-Bacterial AgentsbaysilonBiocompatible MaterialsDimethylpolysiloxanesNitric OxideS-Nitroso-N-Acetylpenicillamineand biomedical applicationsantibiotic resistancebacterial infectionsbacteriophagesmedical devicesnitric oxidethrombosis

Identifiers

PMID39895136
PMCPMC11836933

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.