ArticleBJPsych open2025
Casual associations between frailty and nine mental disorders: bidirectional Mendelian randomisation study.
Article in BJPsych open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Doctors' and Pharmacists' knowledge, skills, and perception of mental frailty in older adults: a scoping review.BMC primary care · 2026Article
- Suicide in later life: the role of frailty and depression.Current opinion in psychiatry · 2025Review
- Frailty as a Predictor of Post-Traumatic Stress Disorder After Advance Care Planning Communication Intervention by Trained Care Managers in Long-Term Care Service Users in Japan: A Secondary Analysis.Journal of personalized medicine · 2025Article
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Authors and funding
9 authors.
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Abstract
backgroundAn increasing number of observational studies have reported associations between frailty and mental disorders, but the causality remains ambiguous.
aimsTo assess the bidirectional causal relationship between frailty and nine mental disorders.
methodWe conducted a bidirectional two-sample Mendelian randomisation on genome-wide association study summary data, to investigate causality between frailty and nine mental disorders. Causal effects were primarily estimated using inverse variance weighted method. Several secondary analyses were applied to verify the results. Cochran's
resultsGenetically determined frailty was significantly associated with increased risk of major depressive disorder (MDD) (odds ratio 1.86, 95% CI 1.36-2.53,
conclusionsOur findings show bidirectional causal associations between frailty and MDD, insomnia and neuroticism. Additionally, higher frailty levels are associated with anxiety and PTSD, and suicide attempts are correlated with increased frailty. Understanding these associations is crucial for the effective management of frailty and improvement of mental disorders.
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