Evidence map›Paper›PMID 39895063›Full record

ArticleCerebral cortex (New York, N.Y. : 1991)2025

Bifocal tACS over the primary sensorimotor cortices increases interhemispheric inhibition and improves bimanual dexterity.

Brooke Lebihan, Lauren Mobers, Shannae Daley, Ruth Battle, Natasia Leclercq, Katherine Misic, Kym Wansbrough, Ann-Maree Vallence, Alexander Tang, Michael Nitsche and 1 more

Abstract read
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In one paragraph

Article in Cerebral cortex (New York, N.Y. : 1991), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Variable E-field properties of dual-site tACS with phase lags.Imaging neuroscience (Cambridge, Mass.) · 2026
    Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Brooke LebihanSchool of Psychology, Murdoch University, Western Australia, 90 South Street, Murdoch, WA 6150, Australia.
Lauren MobersSchool of Psychology, Murdoch University, Western Australia, 90 South Street, Murdoch, WA 6150, Australia.
Shannae DaleySchool of Psychology, Murdoch University, Western Australia, 90 South Street, Murdoch, WA 6150, Australia.
Ruth BattleSchool of Psychology, Murdoch University, Western Australia, 90 South Street, Murdoch, WA 6150, Australia.
Natasia LeclercqSchool of Psychology, Murdoch University, Western Australia, 90 South Street, Murdoch, WA 6150, Australia.
Katherine MisicSchool of Psychology, Murdoch University, Western Australia, 90 South Street, Murdoch, WA 6150, Australia.
Kym WansbroughSchool of Psychology, Murdoch University, Western Australia, 90 South Street, Murdoch, WA 6150, Australia.
Ann-Maree VallenceSchool of Psychology, Murdoch University, Western Australia, 90 South Street, Murdoch, WA 6150, Australia.
Alexander TangExperimental and Regenerative Neurosciences, The University of Western Australia, 35 Stirling Hwy, Crawley, WA 6009, Australia.
Michael NitscheDepartment of Psychology and Neurosciences, Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Ardeystraße 67, 44139 Dortmund, Germany.
Hakuei FujiyamaSchool of Psychology, Murdoch University, Western Australia, 90 South Street, Murdoch, WA 6150, Australia.

Funding

Neurotrauma Research Program DoH20193370Sarich Family Research Fellowship
6 · The paper itself

Abstract

Concurrent application of transcranial alternating current stimulation over distant cortical regions has been shown to modulate functional connectivity between stimulated regions; however, the precise mechanisms remain unclear. Here, we investigated how bifocal transcranial alternating current stimulation applied over the bilateral primary sensorimotor cortices modulates connectivity between the left and right primary motor cortices (M1). Using a cross-over sham-controlled triple-blind design, 37 (27 female, age: 18 to 37 yrs) healthy participants received transcranial alternating current stimulation (1.0 mA, 20 Hz, 20 min) over the bilateral sensorimotor cortices. Before and after transcranial alternating current stimulation, functional connectivity between the left and right M1s was assessed using imaginary coherence measured via resting-state electroencephalography and interhemispheric inhibition via dual-site transcranial magnetic stimulation protocol. Additionally, manual dexterity was assessed using the Purdue pegboard task. While imaginary coherence remained unchanged after stimulation, beta (20 Hz) power decreased during the transcranial alternating current stimulation session. Bifocal transcranial alternating current stimulation but not sham strengthened interhemispheric inhibition between the left and right M1s and improved bimanual assembly performance. These results suggest that improvement in bimanual performance may be explained by modulation in interhemispheric inhibition, rather than by coupling in the oscillatory activity. As functional connectivity underlies many clinical symptoms in neurological and psychiatric disorders, these findings are invaluable in developing noninvasive therapeutic interventions that target neural networks to alleviate symptoms.

Indexed as

Functional LateralityMotor CortexMotor SkillsNeural InhibitionPsychomotor PerformanceSensorimotor CortexTranscranial Direct Current StimulationAdolescentAdultCross-Over StudiesDouble-Blind MethodElectroencephalographyEvoked Potentials, MotorFemaleHumansMaleelectroencephalogramfunctional connectivityinterhemispheric inhibitiontranscranial alternating current stimulationtranscranial magnetic stimulation

Identifiers

PMID39895063
PMCPMC11814492

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.