Evidence map›Paper›PMID 39895012›Full record

ArticleKorean journal of anesthesiology2025

Mortality and factors associated with acute exacerbation after non-cardiac surgery in patients with interstitial pneumonia: a retrospective study.

Kaoru Umehara, Kazuhiro Shirozu, Taichi Ando, Kentaro Tokuda, Kei Makishima, Kazuya Imura, Shota Tsumura, Shinnosuke Takamori, Ken Yamaura

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Korean journal of anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kaoru UmeharaKyushu University Hospital, Fukuoka, Japan.
Kazuhiro ShirozuKyushu University Hospital, Fukuoka, Japan.
Taichi AndoKyushu University Hospital, Fukuoka, Japan.
Kentaro TokudaIntensive Care Unit, Kyushu University Hospital, Fukuoka, Japan.
Kei MakishimaDepartment of Anesthesiology and Critical Care Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Kazuya ImuraDepartment of Anesthesiology and Critical Care Medicine, Kyushu University Hospital, Fukuoka, Japan.
Shota TsumuraDepartment of Anesthesiology and Critical Care Medicine, Kyushu University Hospital, Fukuoka, Japan.
Shinnosuke TakamoriDepartment of Anesthesiology and Critical Care Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Ken YamauraDepartment of Anesthesiology and Critical Care Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute exacerbation of interstitial pneumonia (AE-IP) is associated with high mortality rates. Although the risk factors for AE-IP have been extensively studied, given the small sample sizes, only a few risk factors have been established. This study aimed to investigate the postoperative mortality and factors associated with AE-IP.

methodsThis retrospective study included 482 patients with a preoperative diagnosis of IP who underwent noncardiac surgery between December 2012 and April 2020. AE-IP was diagnosed by a radiologist using computed tomography when worsening respiratory symptoms were observed within 1 month postoperatively. The Cox proportional hazards model was used to compare mortality rates. Candidate factors associated with AE-IP were identified through logistic regression analysis using the variable selection method, followed by case-control analysis using propensity score matching to determine possible factors associated with AE-IP.

resultsThe multivariable-adjusted hazard ratios for all-cause and IP-related deaths were significantly higher in patients with AE-IP than in those without AE-IP. Multivariable analysis with variable selection suggested that male sex, higher C-reactive protein (CRP) levels, fraction of inspired oxygen (FiO2) ≥ 60%, and non-lung surgery were candidate factors associated with AE-IP. Case-control analysis using propensity score matching demonstrated that patients with AE-IP had higher CRP levels (P = 0.044) and frequency of FiO2 ≥ 60% (P = 0.035) than those without AE-IP. Furthermore, a positive, nearly linear relationship was observed between FiO2 ≥ 60% duration and AE-IP incidence.

conclusionsIntraoperative management with FiO2 ≥ 60% and high preoperative CRP levels were significantly associated with postoperative AE-IP.

Indexed as

Lung Diseases, InterstitialPostoperative ComplicationsAgedCase-Control StudiesC-Reactive ProteinDisease ProgressionFemaleHumansMaleMiddle AgedRetrospective StudiesRisk FactorsC-Reactive ProteinC-reactive proteinGeneral surgeryInterstitial pneumoniaLung diseasesMortalityOxygenSurgery

Identifiers

PMID39895012
PMCPMC12489585

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.