Evidence map›Paper›PMID 39894877›Full record

Trial reportJournal of perinatology : official journal of the California Perinatal Association2025

Early exclusive enteral feeding in 30-33 weeks gestation infants: a randomized controlled trial.

Belal N Alshaikh, Ossama Hassan, Wissam Alburaki, Dinesh Dharel, Adel Elsharkawy, Nalini Singal, Kamran Yusuf, Essa Al Awad

Registry-linked trialAbstract readRandomized Controlled TrialPragmatic Clinical Trial
PubMed Publisher
In one paragraph

Trial report in Journal of perinatology : official journal of the California Perinatal Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03708068 (Early Exclusive Enteral Nutrition in Stable Preterm Infants at 30 0/7 - 33 6/7 Weeks Gestation), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03708068 nacompletednot on this map

Early Exclusive Enteral Nutrition in Stable Preterm Infants at 30 0/7 - 33 6/7 Weeks Gestation: A Randomized Controlled Trial

TypeinterventionalSponsorBelal AlshaikhRan2019 to 2024Enrolled69ConditionsEnteral NutritionArmsEarly exclusive enteral nutrition
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Belal N AlshaikhNeonatal Gastroenterology and Nutrition Program, Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. balshaik@ucalgary.ca.ORCID http://orcid.org/0000-0002-6080-6888
Ossama HassanNeonatal Gastroenterology and Nutrition Program, Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Wissam AlburakiDepartment of Pediatrics, Dalhousie University, Halifax, NS, Canada.
Dinesh DharelDepartment of Pediatrics, University of Alberta, Edmonton, AB, Canada.
Adel ElsharkawyNeonatal Gastroenterology and Nutrition Program, Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Nalini SingalNeonatal Gastroenterology and Nutrition Program, Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Kamran YusufNeonatal Gastroenterology and Nutrition Program, Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.ORCID http://orcid.org/0000-0001-5270-5326
Essa Al AwadNeonatal Gastroenterology and Nutrition Program, Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate feasibility and efficacy of early exclusive enteral feeding (EEEF) in reducing time to achieve full enteral feeds.

methodsA pragmatic randomized controlled trial of infants born at 30

resultsSeventy infants were enrolled. Infants in EEEF group achieved full feeds sooner [Mean difference (MD) -1.2 (95%CI -1.8, -0.7)], required fewer hours of parenteral nutrition [0 (IQR 0, 19) vs. 91 (IQR 48, 132) hours, P < 0.001], had less need for central venous access (11.4% vs. 37.1%, P = 0.01) and had shorter hospital stays [MD -6.6 (95%CI -12.9, -0.2) days].

conclusionEarly exclusive enteral feeding in 30

trial registrationClinicalTrials.gov: NCT03708068.

Indexed as

Enteral NutritionFeasibility StudiesFemaleGestational AgeHumansInfant, NewbornInfant, PrematureLength of StayMaleParenteral NutritionTime Factors

Identifiers

PMID39894877

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.