Evidence map›Paper›PMID 39894862›Full record

Observational studyEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2025

Central-venous-catheter-related bloodstream infections in adult patients with sickle cell disease: a retrospective, two-centre study.

Matthieu Holub, David Lebeaux, Patrick Grohs, Laure Joseph, Olivier Pellerin, Geoffrey Cheminet, Najiby Kassis, Salomé Abdellaoui, Jacques Pouchot, Brigitte Ranque and 2 more

Abstract readMulticenter StudyObservational Study
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In one paragraph

Observational study in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Matthieu HolubService de Médecine Interne, Hôpital Européen George Pompidou, Assistance Publique - Hôpitaux de Paris (AP-HP), Sorbonne Université, 20 Rue Leblanc, 75015, Paris, France.
David LebeauxService de maladies infectieuses et tropicales, Hôpital Saint-Louis Lariboisière, Assistance Publique - Hôpitaux de Paris (AP-HP), Université Paris Cité, 1 Avenue Claude Vellefaux, Paris, 75010, France.
Patrick GrohsService de Microbiologie, Hôpital Européen George Pompidou, Assistance Publique - Hôpitaux de Paris (AP-HP), Université Paris Cité, 20 Rue Leblanc, 75015, Paris, France.
Laure JosephService d'hématologie, Hôpital Necker Enfants-Malades, Assistance Publique - Hôpitaux de Paris (AP-HP), Université Paris Cité, 149 Rue de Sèvres, Paris, 75015, France.
Olivier PellerinService de Radiologie, Hôpital Européen George Pompidou, Assistance Publique - Hôpitaux de Paris (AP-HP), Université Paris Cité, 20 Rue Leblanc, 75015, Paris, France.
Geoffrey CheminetService de Médecine Interne, Hôpital Européen George Pompidou, Assistance Publique - Hôpitaux de Paris (AP-HP), Sorbonne Université, 20 Rue Leblanc, 75015, Paris, France.
Najiby KassisService d'hygiène hospitalière, Hôpital Européen George Pompidou, Assistance Publique - Hôpitaux de Paris (AP-HP), Université Paris Cité, 20 Rue Leblanc, Paris, 75015, France.
Salomé AbdellaouiService de Médecine Interne, Hôpital Européen George Pompidou, Assistance Publique - Hôpitaux de Paris (AP-HP), Sorbonne Université, 20 Rue Leblanc, 75015, Paris, France.
Jacques PouchotService de Médecine Interne, Hôpital Européen George Pompidou, Assistance Publique - Hôpitaux de Paris (AP-HP), Sorbonne Université, 20 Rue Leblanc, 75015, Paris, France.
Brigitte RanqueService de Médecine Interne, Hôpital Européen George Pompidou, Assistance Publique - Hôpitaux de Paris (AP-HP), Sorbonne Université, 20 Rue Leblanc, 75015, Paris, France.
Jean Benoit ArletService de Médecine Interne, Hôpital Européen George Pompidou, Assistance Publique - Hôpitaux de Paris (AP-HP), Sorbonne Université, 20 Rue Leblanc, 75015, Paris, France.
Emmanuel LafontService de Médecine Interne, Hôpital Européen George Pompidou, Assistance Publique - Hôpitaux de Paris (AP-HP), Sorbonne Université, 20 Rue Leblanc, 75015, Paris, France. emmanuel.lafont@aphp.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAlthough catheter-related infections are the leading cause of bloodstream infections in patients with sickle cell disease (SCD), data are scarce in adult patients. The objectives of the present study were to describe central-venous-catheter-related bloodstream infections in patients with SCD and identify risk factors.

methodsWe conducted a retrospective, observational study of adult patients with SCD diagnosed with central-venous-catheter-related bloodstream infections between 2011 and 2023 in two SCD reference centres. Each patient with SCD and a bloodstream infection related to a totally implantable venous access port was matched with two control patients with SCD and an infection-free totally implantable venous access port.

resultsThirty-five (6.6%) of the 534 patients experienced a total of 69 central-venous-catheter-related bloodstream infections. Concomitant vaso-occlusive crises were observed for 81.2% of the infections. The 30-day mortality rate was 2.8%, and the infection recurrence rate was 45.7%. We observed 26 totally implantable venous access port-related bloodstream infections in 19 patients, with an incidence rate of 0.31 per 1000 catheter-days. After adjustment, the frequency of hospital admission for a vaso-occlusive crisis (odds ratio (OR) [95% confidence interval (CI)] = 1.6 [1.2-2.4]) and the presence of a psychiatric comorbidity (19.8 [4.0-148.1]) remained significantly associated with totally implantable venous access port-related bloodstream infections. Suboptimal antibiotic levels were observed in five (39%) of the 13 patients having undergone therapeutic drug monitoring. The treatment failed in four (80%) of the five patients, who presented with glomerular hyperfiltration.

conclusionA central-venous-catheter-related bloodstream infection is a severe complication in adult patients with SCD and is associated with psychiatric comorbidities and severe SCD.

Indexed as

Anemia, Sickle CellBacteremiaCatheterization, Central VenousCatheter-Related InfectionsCentral Venous CathetersAdultAgedFemaleHumansIncidenceMaleMiddle AgedRetrospective StudiesRisk FactorsYoung AdultBloodstream infectionCentral venous catheterSickle cell disease

Identifiers

PMID39894862

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.