Evidence map›Paper›PMID 39894854›Full record

ArticleCurrent microbiology2025

Paeonol Inhibits the Replication of Bovine Herpesvirus Type 1 In Vitro Through Regulating the PI3K/AKT Pathway.

Xueying Yuan, Hongrui Wang, Zhicheng Zhao, Chuang Li, Xingyuan Wang, Yu Liu, Yulong Zhou, Zhanbo Zhu, Zecai Zhang

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Current microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Xueying Yuan *College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, 163319, China.
Hongrui Wang *College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, 163319, China.
Zhicheng ZhaoCollege of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, 163319, China.
Chuang LiCollege of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, 163319, China.
Xingyuan WangCollege of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, 163319, China.
Yu LiuCollege of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, 163319, China.
Yulong ZhouCollege of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, 163319, China.
Zhanbo ZhuCollege of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, 163319, China. zhanbozhu@byau.edu.cn.
Zecai ZhangCollege of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, 163319, China. zczhang89@126.com.

Funding

Heilongjiang Bayi Agricultural University XYB202014Heilongjiang Province's "Jie Bang Gua Shuai" Science and Technology Research Project 2023ZXJ02B03Heilongjiang Provincial Postdoctoral Science Foundation LBH-Q20054
6 · The paper itself

Abstract

The bovine herpesvirus type I (BHV-1) is a significant pathogen that poses a threat to the healthy development of the cattle industry and has a global prevalence. Paeonol is a phenolic constituent extracted from the dried root bark of peony in the buttercup family. Although paeonol has anti-inflammatory and antioxidant effects, its antiviral capacity remains unclear. Here, we conducted a cytotoxicity assay to screen the safe concentration of the paeonol using bovine turbinate (BT) cells as a model. Antiviral studies showed that paeonol inhibited BHV-1 gB gene and VP8 protein expression, and reduced cytopathic effect and viral titer. Furthermore, paeonol also demonstrated a potent effect on BHV-1 replication with an EC

Indexed as

AcetophenonesAntiviral AgentsHerpesvirus 1, BovinePhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktVirus ReplicationAnimalsCattleCell LineMolecular Docking SimulationSignal TransductionAcetophenonesAntiviral AgentspaeonolPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-akt

Identifiers

PMID39894854

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.