Evidence map›Paper›PMID 39894789›Full record

ArticlePsychophysiology2025

Attenuated Doors-Locked P300 Amplitude and Elevated Depressive Symptoms: Effects of Age and Sex in Two Independent Samples of Youth.

Nicholas J Santopetro, Nader Amir, Brady D Nelson, Daniel N Klein, Greg Hajcak

Abstract read
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In one paragraph

Article in Psychophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

5 authors.

Nicholas J SantopetroDepartment of Psychology, Florida State University, Tallahassee, Florida, USA.ORCID 0000-0001-8494-1411
Nader AmirDepartment of Psychology, San Diego State University, San Diego, California, USA.
Brady D NelsonDepartment of Psychology, Stony Brook University, Stony Brook, New York, USA.
Daniel N KleinDepartment of Psychology, Stony Brook University, Stony Brook, New York, USA.
Greg HajcakSchool of Education and Counseling Psychology, Santa Clara University, Santa Clara, California, USA.ORCID 0000-0002-5159-7180

Funding

Trajectories of Reward Sensitivity and Depression Across AdolescenceR01MH097767 · NIMH · STATE UNIVERSITY NEW YORK STONY BROOK · PI NELSON, BRADY D · 2012 to 2022
$6.0M
Attention Training to Modify ERN and Risk for Anxiety in AdolescenceR01MH106477 · NIMH · STATE UNIVERSITY NEW YORK STONY BROOK · PI AMIR, NADER, HAJCAK, GREG · 2016 to 2020
$3.2M
FIC NIH HHS MH097767NIMH NIH HHS 7R01MH106477-02NIMH NIH HHS R01 MH097767NIMH NIH HHS R01 MH106477
6 · The paper itself

Abstract

Deficits in cognitive and reward-related functions, measured via reductions in the P300 and reward positivity (RewP) event-related potential (ERP) components, are commonly observed in adults suffering with depression. Considering higher risk for depression emerges among females in adolescence, examination of the neurological underpinnings of depression during this critical developmental period can help further elucidate our overall understanding of the etiology of depressive disorders. Therefore, the present study sought to first examine associations between doors-locked P300 amplitude, RewP amplitude, current depression symptoms, and age in an all-female youth sample (sample 1: n = 296; age, 8 to 14). Next, we examined these same associations, as well as sex, in a second independent sample consisting of male and female youths (sample 2: n = 605; age, 11 to 14). Blunted doors-locked P300 was associated with higher depressive symptoms in both samples. Moreover, the association between P300 and depression was stronger among older youths in both samples. Sex further moderated this relationship in sample 2 such that smaller P300 related to greater depression only in females. There were no consistent associations between RewP amplitude and depressive symptoms in either youth sample. These findings suggest that the doors-locked P300 component is a reliable neural correlate of depression in youth that might specifically relate to pathways linked to increased risk for depression among adolescent females.

Indexed as

DepressionEvent-Related Potentials, P300RewardAdolescentAge FactorsChildElectroencephalographyFemaleHumansMaleSex FactorsadolescencedepressionEEGERPP300RewP

Identifiers

PMID39894789
PMCPMC11793339

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.