ArticleAnnals of dermatology2025
Identification of a Novel Three-immunogene Diagnostic Signature for Alopecia Areata.
Article in Annals of dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Autonomic Signature-Driven Anesthesia Depth Monitoring with Biomimetic Wearable ECG and Knowledge Graph-Augmented Deep Networks.Sensors (Basel, Switzerland) · 2026Article
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Authors and funding
4 authors.
Funding
Abstract
backgroundAutoimmune mechanisms have important roles in the pathogenesis of alopecia areata (AA).
objectiveThis study aimed to evaluate the exact biological and clinical importance of immunogenes in AA patients using bioinformatic methods.
methodsFive AA scalp gene expression profiles were obtained from the Gene Expression Omnibus database. Differentially-expressed genes (DEGs) between AA and control groups were identified. An immune-related gene diagnostic signature (IRGDS) was established by protein-protein interaction network analysis, least absolute shrinkage and selection operator and logistic regression analysis.
resultsA total of 102 immune-related DEGs were identified. We developed an IRGDS composed of CD8A, CSF1R and CXCL10 for AA molecular pathological assessment and diagnosis (area under the receiver operating characteristic curve [AUC]=0.962). We also validated the diagnostic value of the IRGDS in an external cohort (AUC=0.955). Patients with high IRGDS scores presented with a higher abundance of immune cell infiltration and expression of genes associated with immune recruitment and immune activation, suggesting adverse biological alterations.
conclusionIn our study, an IRGDS model with accurately diagnostic capacity for AA was established, and biological alterations were deciphered in AA. The IRGDS may be used as an auxiliary diagnostic marker for AA.
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