Evidence map›Paper›PMID 39894497›Full record

ArticleInternal medicine (Tokyo, Japan)2025

Osseous Sarcoid-like Reaction in Sigmoid Colon Cancer Requiring Differentiation from Bone Metastasis.

Ayane Higashi, Hiroto Inoue, Hiroshi Matsumoto, Soichiro Tani, Kenji Isokawa, Hiroyuki Aoyama, Shuhei Shintani, Takayuki Imai, Masashi Ohno, Hidenori Kimura and 5 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ayane HigashiSchool of Medicine, Shiga University of Medical Science, Japan.
Hiroto InoueDepartment of Endoscopy, Shiga University of Medical Science, Japan.
Hiroshi MatsumotoDivision of Gastroenterology, Department of Medicine, Shiga University of Medical Science, Japan.
Soichiro TaniDepartment of Surgery, Shiga University of Medical Science, Japan.
Kenji IsokawaDepartment of Pathology, Shiga University of Medical Science, Japan.
Hiroyuki AoyamaDivision of Gastroenterology, Department of Medicine, Shiga University of Medical Science, Japan.
Shuhei ShintaniDivision of Gastroenterology, Department of Medicine, Shiga University of Medical Science, Japan.
Takayuki ImaiDivision of Gastroenterology, Department of Medicine, Shiga University of Medical Science, Japan.
Masashi OhnoDivision of Gastroenterology, Department of Medicine, Shiga University of Medical Science, Japan.
Hidenori KimuraDepartment of Endoscopy, Shiga University of Medical Science, Japan.
Toru MiyakeDepartment of Surgery, Shiga University of Medical Science, Japan.
Atsushi NishidaSchool of Medicine, Shiga University of Medical Science, Japan.
Ryoji KushimaDivision of Gastroenterology, Department of Medicine, Shiga University of Medical Science, Japan.
Masaji TaniDepartment of Endoscopy, Shiga University of Medical Science, Japan.
Osamu InatomiSchool of Medicine, Shiga University of Medical Science, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although sarcoid-like reactions are uncommon in colorectal cancer, they can coexist with other cancers. We herein report a 50-year-old woman with sigmoid adenocarcinoma and osseous sarcoid-like reactions that resembled metastases. Positron emission tomography-computed tomography revealed an uptake in the iliac bone and para-aortic lymph nodes. The depth of invasion indicates non-metastatic lesions. Bone and lymph node biopsies revealed epithelioid non-caseating granulomas with bone trabeculae, resulting in a final diagnosis of pathological T2N2aM0, Stage IIIB. When the expected depth of invasion differs from that of typical bone metastases, colorectal cancer-associated bone lesions should be evaluated for sarcoid-like reactions.

Indexed as

AdenocarcinomaBone NeoplasmsSarcoidosisSigmoid NeoplasmsDiagnosis, DifferentialFemaleHumansMiddle AgedPositron Emission Tomography Computed Tomographycolon cancerdiagnosisdifferentialiliac boneneoplasm metastasissarcoid reaction

Identifiers

PMID39894497
PMCPMC12393919

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.