Evidence map›Paper›PMID 39894488›Full record

ArticleInternal medicine (Tokyo, Japan)2025

Primary Cutaneous CD8-positive Aggressive Epidermotropic Cytotoxic T-cell Lymphoma Complicated by Paraneoplastic Encephalitis.

Yu Inoue, Taku Tsukamoto, Kentaro Mizuhara, Chika Maekura, Takahisa Nakamura, Haruya Okamoto, Takahiro Fujino, Shinsuke Mizutani, Yuji Shimura, Ayano Maruyama and 7 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Yu InoueDivision of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
Taku TsukamotoDivision of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
Kentaro MizuharaDivision of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
Chika MaekuraDivision of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
Takahisa NakamuraDivision of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
Haruya OkamotoDivision of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
Takahiro FujinoDivision of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
Shinsuke MizutaniDivision of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
Yuji ShimuraDivision of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
Ayano MaruyamaDepartment of Dermatology, Kyoto Prefectural University of Medicine, Japan.
Mari NakanishiDepartment of Dermatology, Kyoto Prefectural University of Medicine, Japan.
Eijirou TanakaDepartment of Neurology, Kyoto Prefectural University of Medicine, Japan.
Yuki NishidaDepartment of Neurology, Kyoto Prefectural University of Medicine, Japan.
Kenta IshiiDepartment of Neurology, Kyoto Prefectural University of Medicine, Japan.
Yuta SonobeDepartment of Surgical Pathology, Kyoto Prefectural University of Medicine, Japan.
Aya Miyagawa-HayashinoDepartment of Surgical Pathology, Kyoto Prefectural University of Medicine, Japan.
Junya KurodaDivision of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary cutaneous CD8-positive aggressive epidermotropic cytotoxic T-cell lymphoma (PCAE-CTL) is a rare subtype of cutaneous T-cell lymphoma with a poor prognosis. We herein report a case of PCAE-CTL accompanied by anti-Ma2 antibody-positive paraneoplastic encephalitis. A 33-year-old woman with erythema and disturbance of consciousness was diagnosed with PCAE-CTL by a skin biopsy. Head magnetic resonance imaging revealed bilateral medial temporal lobe hyperintensity, and anti-Ma2 antibody in the cerebrospinal fluid was positive. She was diagnosed with concurrent anti-Ma2 antibody-positive paraneoplastic encephalitis. In cases of lymphoma with brain lesions, invasion of the central nervous system by lymphoma and paraneoplastic encephalitis should be considered.

Indexed as

CD8-Positive T-LymphocytesEncephalitisLymphoma, T-Cell, CutaneousParaneoplastic Syndromes, Nervous SystemSkin NeoplasmsT-Lymphocytes, CytotoxicAdultAntigens, NeoplasmFemaleHumansMagnetic Resonance ImagingNerve Tissue ProteinsAntigens, NeoplasmMa2 antigenNerve Tissue Proteinsanti-Ma2 antibodyparaneoplastic encephalitisprimary cutaneous CD8-positive aggressive epidermotropic cytotoxic T-cell lymphoma

Identifiers

PMID39894488
PMCPMC12463409

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.