ArticleThe Annals of thoracic surgery2025
Paravalvular Leak After Transcatheter Aortic Valve Implantation: Results From 3600 Patients.
Article in The Annals of thoracic surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Paravalvular Leak After Transcatheter Aortic Valve Implantation: Haemodynamic Consequences, Clinical Impact, and Contemporary Assessment.Journal of cardiovascular development and disease · 2026Review
- Outcomes of Transcatheter Aortic Valve Implantation with Abbott's Portico Compared to Edwards' SAPIEN 3: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Balloon-Expandable Versus Self-Expanding Valves in Low-Flow, Low-Gradient Aortic Stenosis: Does Valve Type Matter?Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2026Article
- TAVI Performance at a Single Center over Several Years: Procedural and Clinical Outcomes.Medicina (Kaunas, Lithuania) · 2026Article
- Comparative Analysis of Perceval and Conventional Bovine Bioprosthetic Valves in Aortic Valve Replacement: Hemodynamics, Reverse Remodeling, and Long-Term Outcomes.Journal of clinical medicine · 2025Article
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Authors and funding
10 authors.
Funding
Abstract
backgroundParavalvular leak (PVL) after transcatheter aortic valve implantation (TAVI) is associated with poor outcomes. Mild PVL remains prevalent after TAVI, and its impact on long-term survival is unclear. This study aimed to examine the incidence, impact on survival, and progression of PVL.
methodsThis was a retrospective, single-institution cohort study of TAVIs between November 2012 and January 2023. Patients were stratified by 30-day PVL severity: none to trace, mild, and moderate to severe. Multivariable logistic regression was performed to identify risk factors associated with increasing PVL severity. Kaplan-Meier survival estimation and Cox proportional hazards regression were performed.
resultsA total of 3600 patients underwent TAVI. Of these, 2719 (75.5%) had none to trace PVL, 808 (22.5%) had mild PVL, and 73 (2.0%) had moderate to severe PVL at 30 days. On multivariable logistic regression, later years of valve implantation (2017-2023) were protective against PVL progression. Kaplan-Meier estimates of the 3 groups were significantly different (P < .001) with the moderate to severe group having reduced survival. On Cox regression, moderate to severe PVL was associated with increased mortality (hazard ratio, 1.80; 95% Cl, 1.31-2.46; P < .001), whereas mild PVL was not (hazard ratio, 1.01; 95% CI, 0.89-1.15; P = .88) compared with none to trace PVL. For Kaplan-Meier estimates comparing the none to trace and mild PVL groups alone, landmark analysis showed reduced survival in the mild PVL group after 2 years (P = .03); however, this late reduction in survival in the mild PVL group did not persist on multivariable analysis (P = .14).
conclusionsAfter TAVI, moderate to severe PVL is associated with reduced survival compared with none to trace PVL. Mild PVL may result in a delayed survival reduction.
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