Evidence map›Paper›PMID 39894415›Full record

ArticleNeuroscience research2025

Positive allosteric modulator of GLT-1 reduces methamphetamine hyperlocomotion, sensitization and conditioned place preference in mice.

Prateek Mokkarala, Sonita Wiah, Ellen M Unterwald, Xiangdang Shi, Danielle R Stern, Andreia C K Fontana, Joseph M Salvino, Scott M Rawls

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Multimodal dynamics control activity of a glial glutamate transporter.bioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Prateek MokkaralaCenter for Substance Abuse Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
Sonita WiahCenter for Substance Abuse Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
Ellen M UnterwaldCenter for Substance Abuse Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA; Department of Neural Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
Xiangdang ShiCenter for Substance Abuse Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
Danielle R SternCenter for Substance Abuse Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
Andreia C K FontanaDepartment of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA, USA.
Joseph M SalvinoMedicinal Chemistry, Molecular and Cellular Oncogenesis (MCO) Program, The Wistar Cancer Center Molecular Screening, The Wistar Institute, Philadelphia, PA, USA.
Scott M RawlsCenter for Substance Abuse Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA; Department of Neural Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA. Electronic address: scott.rawls@temple.edu.

Funding

Pilot Projects Core (PPC)P30DA013429 · NIDA · TEMPLE UNIV OF THE COMMONWEALTH · PI SCOTT M. RAWLS · 2000 to 2026
$34.6M
Non-beta-lactam GLT-1 activators: characterization in preclinical models of opioid and cocaine addictionR01DA051205 · NIDA · TEMPLE UNIV OF THE COMMONWEALTH · PI RAWLS, SCOTT M., REITZ, ALLEN B · 2020 to 2024
$2.1M
NIDA NIH HHS P30 DA013429NIDA NIH HHS R01 DA051205
6 · The paper itself

Abstract

NA-014 is a positive allosteric modulator (PAM) of glutamate transporter subtype 1 (GLT-1) that increases glutamate reuptake. Since enhanced glutamate transmission facilitates methamphetamine (METH) hyperlocomotion, behavioral sensitization, and conditioned place preference (CPP), we hypothesized that NA-014 (60 mg/kg) would reduce these effects in male mice. NA-014 reduced acute ambulation induced by METH and behavioral sensitization during repeated METH. NA-014 given after METH conditioning reduced expression of METH CPP. NA-014 injected during METH conditioning did not affect development of METH CPP, and NA-014 did not affect spatial memory. These results suggest that GLT-1 PAMs reduce METH-induced behavioral effects in mice.

Indexed as

Central Nervous System StimulantsConditioning, PsychologicalExcitatory Amino Acid Transporter 2LocomotionMethamphetamineAllosteric RegulationAnimalsMaleMiceCentral Nervous System StimulantsExcitatory Amino Acid Transporter 2MethamphetamineSlc1a2 protein, mouseCPPGLT-1GlutamateLocomotorMethamphetamineNA-014PAM

Identifiers

PMID39894415
PMCPMC11963643

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.