Evidence map›Paper›PMID 39894345›Full record

ArticleJournal of advanced research2025

Period3 modulates the NAD

Xiaoxian Xie, Haoshen Xu, Ruonan Shu, Shulin Du, Haidan Fan, Mengya Zhang, Lei Sun, Jiafeng Zhou, Liangliang Wang, Zezhi Li and 1 more

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In one paragraph

Article in Journal of advanced research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xiaoxian XieShanghai Mental Health Center, Shanghai Jiao Tong University, School of Medicine, Shanghai 201108, China; Department of Pharmacology, University of Oxford, Mansfield Road OX1 3QT, Oxford, UK; Shanghai Key Laboratory of Psychotic Disorders, Brain Health Institute, Shanghai Mental Health Center, Shanghai 201108, China. Electronic address: xiexiaoxian502@gmail.com.
Haoshen XuCollege of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310032, China.
Ruonan ShuCollege of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310032, China.
Shulin DuDepartment of Nutritional and Metabolic Psychiatry, Affliated Brain Hospital, Guangzhou Medical University, Guangzhou, China; Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou Medical University, Guangzhou, China.
Haidan FanCollege of Animal Science, South China Agricultural University, Guangzhou 510640, China.
Mengya ZhangCollege of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310032, China.
Lei SunCollege of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310032, China.
Jiafeng ZhouCollege of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310032, China.
Liangliang WangCollege of Ecology, Lishui University, Lishui 323000, China.
Zezhi LiDepartment of Nutritional and Metabolic Psychiatry, Affliated Brain Hospital, Guangzhou Medical University, Guangzhou, China; Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou Medical University, Guangzhou, China. Electronic address: biolpsychiatry@126.com.
Daniel C AnthonyDepartment of Pharmacology, University of Oxford, Mansfield Road OX1 3QT, Oxford, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPERIOD (PER)3 deficiency is associated with depression-like behaviors, but the underlying mechanisms remain unclear.

objectivesThis study aims to elucidate the role and mechanism of PER3 in regulating depression-like behaviors in mice.

methodsDepression-like behaviors were assessed using the sucrose preference test, tail suspension test, and forced swimming test. Metabolomic analysis was conducted on hippocampal tissues from Per3 knockout mice using chromatography-mass spectrometry. The regulatory role of PER3 on the expression of nicotinamide phosphoribosyltransferase (Nampt) was investigated through co-immunoprecipitation and chromatin immunoprecipitation assays.

resultsMetabolomic analysis revealed that Per3 deficiency disrupts mitochondrial function, as evidenced by reduced activities of key tricarboxylic acidcycle enzymes (succinate dehydrogenase, citrate synthase, and α-ketoglutarate dehydrogenase), diminished expression of mitochondrial respiratory chain complexes I-V, and decreased nicotinamide adenine dinucleotide (NAD)

conclusionsThese findings uncover a novel mechanism by which PER3 ameliorates depressive behaviors through the regulation of NAMPT-controlled NAD

Indexed as

CytokinesDepressionNADNicotinamide PhosphoribosyltransferaseSirtuin 3AnimalsBehavior, AnimalDisease Models, AnimalHippocampusMaleMiceMice, Inbred C57BLMice, KnockoutMitochondriaCytokinesNADNicotinamide Phosphoribosyltransferasenicotinamide phosphoribosyltransferase, mouseSirt3 protein, mouseSirtuin 3Depression-like behaviorEnergy metabolismMitochondrial complexNAD(+)Per3SIRT3

Identifiers

PMID39894345
PMCPMC12627864

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.