Evidence map›Paper›PMID 39894015›Full record

ArticleOphthalmic research2025

Characterization of Macular Fundus Autofluorescence Changes in Patients with Retinitis Pigmentosa.

Muhammad Jehanzeb Khan, Zainab Rustam, Faiqa Binte Aamir, Maria Chairez Miranda, Imad Shaikh, Anam Akhlaq, Jiawen Liu, Mandeep Singh, Xiangrong Kong, Peter A Campochiaro

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In one paragraph

Article in Ophthalmic research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Muhammad Jehanzeb KhanThe Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA, mkhan112@jhmi.edu.
Zainab RustamThe Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Faiqa Binte AamirThe Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Maria Chairez MirandaThe Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Imad ShaikhThe Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Anam AkhlaqThe Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Jiawen LiuThe Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Mandeep SinghThe Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Xiangrong KongThe Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Peter A CampochiaroThe Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Funding

Wilmer Core Grant for Vision ResearchP30EY001765 · NEI · JOHNS HOPKINS UNIVERSITY · PI Jiang Qian · 1985 to 2026
$22.1M
NAC Attack, a phase-3, multicenter, randomized, placebo-controlled trial in patients with retinitis pigmentosaUG1EY033293 · NEI · JOHNS HOPKINS UNIVERSITY · PI Xiangrong Kong · 2022 to 2026
$18.1M
Developing photoreceptor repair for macular degeneration therapy.R01EY033103 · NEI · JOHNS HOPKINS UNIVERSITY · PI SINGH, MANDEEP · 2021 to 2025
$2.0M
NAC Attack, A Phase-3, Multicenter, Randomized, Placebo-Controlled Trial in Patents with Retinitis PigmentosaUG1EY033286 · NEI · JOHNS HOPKINS UNIVERSITY · PI Peter A Campochiaro · 2022 to 2026
$1.7M
NEI NIH HHS P30 EY001765NEI NIH HHS R01 EY033103NEI NIH HHS UG1 EY033286NEI NIH HHS UG1 EY033293
6 · The paper itself

Abstract

introductionThe aim of this study was to characterized fundus autofluorescence (AF) changes that occur in the macula of patients with retinitis pigmentosa (RP).

methodsWe conducted a case series on 99 patients with RP. Features seen on fundus AF images were evaluated, organized into a grading scheme, and correlated with ellipsoid zone (EZ) width. Patterns of AF changes occurring in the macula and correlation with EZ width.

resultsFour primary fundus AF phenotypes were identified: (1) hyperAF arc, (2) hyperAF ring, (3) hyperAF ring with abnormal hyperAF within the ring, and (4) central hyperAF. The second phenotype was most common and had 3 subgroups, hyperAF rings within the macula, those extending outside the macula, and incomplete rings. HyperAF rings were also characterized as narrow or wide with wide rings having a greater amount of hyperAF. Linear Mixed-Effects Model showed mean measured EZ width was significantly greater for phenotype 1 versus each of the other 3 phenotypes (p < 0.01) and for phenotype 2 versus phenotypes 3 and 4 (p < 0.05), and also differed among phenotype 2 subgroups (p < 0.05). Other AF characteristics identified were focal posterior distinct or indistinct hypoAF which sometimes formed complete or incomplete hypoAF rings surrounding a hyperAF ring, diffuse or focal hyperAF outside hyperAF rings, and the amount of encroachment of peripheral hypoAF.

conclusionsA grading scheme for macular AF features in patients with RP identified phenotypes that correlate with stage of disease based upon EZ width. Longitudinal studies are needed to test whether presumed early AF phenotypes evolve into later phenotypes. Use of the grading scheme for patient populations in interventional trials could help determine if any of the defined AF features provide predictive value for therapeutic responses.

Indexed as

Fluorescein AngiographyMacula LuteaRetinitis PigmentosaAdolescentAdultAgedFemaleFundus OculiHumansMaleMiddle AgedPhenotypeRetrospective StudiesTomography, Optical CoherenceVisual AcuityYoung AdultEllipsoid zoneImagingRetinaRetinal degenerationRetinal dystrophy

Identifiers

PMID39894015
PMCPMC11922654

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.