Evidence map›Paper›PMID 39893912›Full record

ArticleEnvironment international2025

Persistent organochlorine pesticides and cardiometabolic outcomes among middle-aged Latina women in a California agricultural community: The CHAMACOS Maternal Cognition Study.

Marcella Warner, Stephen Rauch, Brenda Eskenazi, Lucia Calderon, Robert B Gunier, Katherine Kogut, Nina Holland, Weihong Guo, Julianna Deardorff, Jacqueline M Torres

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In one paragraph

Article in Environment international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Marcella WarnerCenter for Environmental Research and Community Health (CERCH), School of Public Health, University of California Berkeley, Berkeley, CA, USA. Electronic address: mwarner@berkeley.edu.
Stephen RauchCenter for Environmental Research and Community Health (CERCH), School of Public Health, University of California Berkeley, Berkeley, CA, USA.
Brenda EskenaziCenter for Environmental Research and Community Health (CERCH), School of Public Health, University of California Berkeley, Berkeley, CA, USA.
Lucia CalderonDepartment of Epidemiology & Biostatistics, University of California San Francisco, San Francisco, CA, USA.
Robert B GunierCenter for Environmental Research and Community Health (CERCH), School of Public Health, University of California Berkeley, Berkeley, CA, USA.
Katherine KogutCenter for Environmental Research and Community Health (CERCH), School of Public Health, University of California Berkeley, Berkeley, CA, USA.
Nina HollandDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, Berkeley, CA, USA.
Weihong GuoDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, Berkeley, CA, USA.
Julianna DeardorffCenter for Environmental Research and Community Health (CERCH), School of Public Health, University of California Berkeley, Berkeley, CA, USA.
Jacqueline M TorresDepartment of Epidemiology & Biostatistics, University of California San Francisco, San Francisco, CA, USA.

Funding

Project C: Epigenetic Effects of DDT/E and PBDEs on PubertyP01ES009605 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ESKENAZI, BRENDA · 1999 to 2015
$11.2M
Life-course social adversity, pesticide exposure, and cognitive outcomes among an ongoing cohort of mid-life Latina women in an under served agricultural regionR01AG069090 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI TORRES, JACQUELINE MARIE · 2020 to 2024
$7.8M
DDT & PBDE exposure, puberty onset and neurodevelopment in Mexican-American girlsR01ES017054 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ESKENAZI, BRENDA · 2009 to 2013
$3.2M
Maintaining and Expanding the CHAMACOS Epidemiology Cohort Infrastructure for Future GenerationsR24ES028529 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Robert Gunier · 2017 to 2026
$2.0M
Fostering Scientific and Workforce Diversity by Maintaining and Enriching the CHAMACOS Birth CohortU24ES028529 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI GUNIER, ROBERT · 2023 to 2025
$1.1M
NIA NIH HHS R01 AG069090NIEHS NIH HHS P01 ES009605NIEHS NIH HHS R01 ES017054NIEHS NIH HHS R24 ES028529NIEHS NIH HHS U24 ES028529
6 · The paper itself

Abstract

objectiveEnvironmental exposure to endocrine disrupting compounds is hypothesized to increase risk of cardiovascular disease through effects on obesity, hypertension, dyslipidemia, and insulin resistance. We examined the relationship between serum concentrations of persistent organochlorine pesticides and biologic markers of inflammation and cardiometabolic disease, measured over a decade later, in a cohort of middle-aged and primarily immigrant Latina women living in an underserved agricultural community in California. MATERIAL AND

methodsWe used data from the Center for the Health Assessment of Mothers and Children of Salinas-Maternal Cognition Study (CHAMACOS-MCS). We included 468 women who had concentrations of organochlorine pesticides measured in serum collected in 2009-2011 and complete follow-up data in 2022-2024 (blood draw, anthropometry, personal interview). We used Bayesian hierarchical regression models (BHM) to examine the independent effects of five highly correlated pesticides with continuous and binary measures of cardiometabolic disease and inflammation.

resultsParticipants averaged 49.0 (±5.5) years at follow-up. In BHM models, a 10-fold increase in p,p'-dichlorodiphenyltrichloroethane (DDT) and β-hexacyclohexane (β-HCH) was positively associated with BMI (DDT: adj-β = 1.26, 95 % Credible Interval (CrI): 0.33, 2.20; β-HCH: adj-β = 1.56, 95 %CrI: 0.45, 2.67) and waist circumference (DDT: adj-β = 2.75, 95 %CrI: 0.65, 4.85; β-HCH: adj-β = 3.74, 95 %CrI: 1.24, 6.23). Although credible intervals crossed the null, consistent positive associations were observed for DDT and β-HCH with blood pressure and for DDT with insulin resistance. Trans-nonachlor was positively associated with triglycerides (log-TRIG: adj-β = 0.08, 95 %CrI: 0.02, 0.13). β-HCH was positively associated with inflammatory markers (log-hsCRP: adj-β = 0.11, 95 %CrI: 0.03, 0.19; log-IL-6: adj-β = 0.08, 95 %CrI: 0.03, 0.14).

conclusionWith over a decade of follow-up, we extend evidence on previously reported associations of DDT and β-HCH with several measures of obesity. In addition, we provide new evidence suggesting associations with biomarkers of blood pressure, insulin resistance, dyslipidemia and inflammation, supporting the hypothesis that exposure may have long-term influences on cardiovascular disease risk.

Indexed as

Cardiovascular DiseasesEnvironmental ExposureEnvironmental PollutantsHydrocarbons, ChlorinatedPesticidesAdultAgricultureCaliforniaFemaleHispanic or LatinoHumansMiddle AgedEnvironmental PollutantsHydrocarbons, ChlorinatedPesticidesDichlorodiphenyltrichloroethaneHypertensionInflammationInsulin resistanceObesityOrganochlorine pesticides

Identifiers

PMID39893912
PMCPMC12686108

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.