Evidence map›Paper›PMID 39893721›Full record

ArticleEBioMedicine2025

High risk of asthma among early teens is associated with quantitative differences in mite and cat allergen specific IgE and IgG4: a modified Th2 related antibody response revisited.

Thomas A Platts-Mills, Behnam Keshavarz, Jeffrey M Wilson, Sheryl L Rifas-Shiman, Samuel M Ailsworth, Joanne E Sordillo, Lisa Workman, Martin Chapman, Jonas Lidholm, Emily Oken and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EBioMedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Local allergic asthma to cat allergens.The journal of allergy and clinical immunology. Global · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Thomas A Platts-MillsDivision of Allergy & Clinical Immunology, Department of Medicine, University of Virginia, Charlottesville, VA, USA. Electronic address: tap2z@virginia.edu.
Behnam KeshavarzDivision of Allergy & Clinical Immunology, Department of Medicine, University of Virginia, Charlottesville, VA, USA.
Jeffrey M WilsonDivision of Allergy & Clinical Immunology, Department of Medicine, University of Virginia, Charlottesville, VA, USA.
Sheryl L Rifas-ShimanThe Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Samuel M AilsworthDivision of Allergy & Clinical Immunology, Department of Medicine, University of Virginia, Charlottesville, VA, USA.
Joanne E SordilloThe Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Lisa WorkmanDivision of Allergy & Clinical Immunology, Department of Medicine, University of Virginia, Charlottesville, VA, USA.
Martin ChapmanInBio, Charlottesville, VA, USA.
Jonas LidholmThermo Fisher Scientific, Uppsala, Sweden.
Emily OkenThe Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Diane R GoldThe Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; The Department of Environmental Medicine, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Funding

Prenatal environmental determinants of health in young adulthood: a lifecourse approachR01HD034568 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI Marie-France Hivert, Emily Oken · 1998 to 2026
$20.6M
IgE antibodies to the mammalian oligosaccharide galactose-alpha-1, 3-galactose (alpha-gal): immunology, epidemiology and relevance to allergic and inflammatory diseaseR37AI020565 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI THOMAS A. PLATTS-MILLS · 1992 to 2026
$8.4M
DUST MITE, COCKROACH AND CAT ALLERGENS IN HOUSES/ASTHMAR01AI020565 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI PLATTS-MILLS, THOMAS A. · 1985 to 2017
$7.1M
The Fetal and Childhood Environment, Oxidative Balance, Inflammation and AsthmaR01AI102960 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI GOLD, DIANE R, OKEN, EMILY · 2013 to 2017
$4.0M
Maintain and Enrich Resource Infrastructure for Project Viva: a pre-birth cohort with follow up into adolescenceR24ES030894 · NIEHS · HARVARD PILGRIM HEALTH CARE, INC. · PI OKEN, EMILY · 2020 to 2024
$2.0M
NIAID NIH HHS R01 AI020565NIAID NIH HHS R01 AI102960NIAID NIH HHS R37 AI020565NICHD NIH HHS R01 HD034568NIEHS NIH HHS R24 ES030894
6 · The paper itself

Abstract

backgroundAlthough proteins derived from cats are an important contributor to indoor allergen exposure in relation to asthma, it has been known for at least twenty years that some children who live in a house with a cat can become clinically tolerant to these animals. In 2001, we reported that children exposed to high levels of cat allergens made high levels of IgG4 antibodies to the cat allergen Fel d 1, and we coined the term "a modified Th2 response". However, this phenomenon is still poorly understood.

methodsWe studied serum antibodies among 616 individuals in the Viva unselected birth cohort recruited at their early teen visit (mean age 13.1 SD 0.8). IgE and IgG4 antibodies were measured by ImmunoCAP to inhaled allergens as well as the best characterised component allergens of cat, Fel d 1, Fel d 2, Fel d 4, and Fel d 7, and the dust mite allergens Der p 1, Der p 2, Der p 10, and Der p 23.

findingsThe results confirm that young teens living in a home with a cat make high levels of IgG4 specific for cat allergens, and that those antibodies, and specifically those to Fel d 1 are negatively associated with asthma. By contrast, the IgG4 responses to Fel d 4 and Fel d 7 are significantly lower and have no significant association with asthma. Perhaps more surprisingly, a similar effect is seen in relation to dust-mite allergens. Although the allergen Der p 1 is a major part of the IgE response to mite allergens, this protein also induced high prevalence and levels of IgG4 antibodies and has a less strong relationship to asthma than IgE to Der p 2 or Der p 23. Indeed, values of specific IgE to Der p 1 >3.5 IU/mL were not significantly related to asthma (OR 1.5 CI 0.8-2.8, p = 0.3, Chi

interpretationHigh exposure to specific allergens in household dust can enhance production of both sIgE and sIgG4 antibodies, while allergens where abundance is significantly lower in dust can induce sIgE with limited or no sIgG4. The result is that the less abundant allergens, i.e., Fel d 4, Fel d 7, Der p 2, and Der p 23, may have a significantly higher relevance to asthma than expected because they induce less sIgG4.

fundingThis work was funded by R01-AI20565 (TPM) and support for the IgE and IgG4 assays provided by Phadia/Thermo Fisher Kalamazoo, Michigan. Project Viva is also supported by NIH R01HD034568 and R24ES.

Indexed as

AllergensAsthmaImmunoglobulin EImmunoglobulin GMitesTh2 CellsAdolescentAnimalsAntigens, DermatophagoidesCatsChildFemaleGlycoproteinsHumansMaleAllergensAntigens, DermatophagoidesFel d 1 protein, Felis domesticusGlycoproteinsImmunoglobulin EImmunoglobulin GAsthmaComponent allergens from cat and miteEarly teensIgE and IgG4 antibodiesLess abundant allergens in house dust

Identifiers

PMID39893721
PMCPMC11840499

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.